Synthesis, Structure, and Biological Activity of Coppercarbamothioyl]hydrazinylidene}propanoic Acid

2-Oxopropanoic acid reacts in ethanol with N-(prop-2-en-1-yl)hydrazinecarbothioamide in a 1 : 1 mole ratio to form thiosemicarbazone H.sub.2L. Coordination compounds Cu(HL)X [X = Cl.sup.-, Br.sup.-, NO.sub.3.sup.-], Cu(H.sub.2O)(L), Ni(HL).sub.2, Co(HL).sub.2X [X = Cl.sup.-, Br.sup.-], and Fe(HL).sub.2X [X = NO.sub.3.sup.-, Br.sup.-] are formed in the reactions of H.sub.2L with copper(II), nickel(II), cobalt(II), and iron(III) salts. The reactions of Cu(H.sub.2O)(L) with imidazole (Im) and 3,4-dimethylpyridine (3,4-Lut) result in mixed-ligand complexes Cu(A)(L) [A = Im, 3,4-Lut]. The structures of two copper complexes were determined by single crystal X-ray diffraction analysis. The synthesized complexes exhibit selective antimicrobial and antifungal activity in the concentration range of 15.62-1000 [mu]g/mL. The introduction of amines into the inner sphere of copper complexes leads to an increase in the antimicrobial activity.