Chemistry in a Bottle: Ester Formation in Acidified Mobile-Phase Solvents: Acidified solvents are commonly used in reversed-phase liquid chromatography to adjust mobile-phase pH and the ionization state of ionogenic compounds. When methanol-containing solvents are acidified with formic or trifluoroacetic acids, esters can be formed at chromatographically relevant rates, affecting baseline quality, retention, and selectivity. Understanding these effects is the first step toward avoiding the probl

Chemistry in a Bottle: Ester Formation in Acidified Mobile-Phase Solvents: Acidified solvents are commonly used in reversed-phase liquid chromatography to adjust mobile-phase pH and the ionization state of ionogenic compounds. When methanol-containing solvents are acidified with formic or trifluoroacetic acids, esters can be formed at chromatographically relevant rates, affecting baseline quality, retention, and selectivity. Understanding these effects is the first step toward avoiding the probl

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Veröffentlicht in:LC GC North America 2022-09, Vol.40 (9), p.411
Hauptverfasser: Metzger, Benedikt, Shoykhet, Konstantin, Buckenmaier, Stephan, Stoll, Dwight R
Format: Magazinearticle
Sprache:eng
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ISSN:1527-5949