Hematological Parameter as Predictor Mortality in Acute Myocardial Infarction Patients

Purpose: Acute myocardial infarction (AMI) is one of the leading causes of death in the world. Several hematological parameters are involved in AMI conditions and can be explored for their ability to predict in-hospital mortality. We evaluated hematological parameter value as predictors of in-hospital mortality in AMI patients. Patients and Methods: Analytical observational study on AMI patients that admitted to Dr. Saiful Anwar Hospital, June-August 2021. Complete blood count was taken at the beginning of hospital admission. Patients with sepsis were excluded from the study. The research subjects were divided into two groups, survivor group and non-survivor group (in-hospital mortality). Hematological parameters as predictors of mortality were analyzed using the ROC curve and odds ratio. Results: Among 44 study subjects, 19 (43.18%) patients were in the non-survivor group and 25 (56.82%) patients were in the survivor group. Hematological parameters that can be predictors of mortality include leukocytes (AUC = 0.744; p = 0.006), neutrophils (AUC = 0.729; p = 0.010), eosinophils (AUC = 0.696; p = 0.028), and eosinophils/leukocytes ratio (AUC = 0.772; p = 0.012). The cut-off value for leukocytes was 13,725/[micro]L (OR: 9), neutrophils was 12,008/[micro]L (OR: 8.14), eosinophils was 58.3/[micro]L (OR: 4.06), and eosinophil/leukocyte ratio was 0.0025 (OR: 4.41) with sensitivity 63.25%, 52.6%, 78.9%, and 63.2%, respectively, and specificity 84%, 88%, 52%, and 72%, respectively. Conclusion: Leukocyte, neutrophils, eosinophils count and eosinophil/leukocyte ratio can help predict in-hospital mortality of AMI patients. Keywords: leukocytes, neutrophils, eosinophils, mortality, acute myocardial infarction