Inclusion Complex of 11-deoxymisoprostol and Glycyrrhizic Acid with Improved Anti-Ulcer Activity

A 1:4 inclusion complex of 11-deoxymisoprostol ( II ) with glycyrrhizic acid (complex III ) was synthesized and exhibited high anti-ulcer activity in experimental models of gastric mucosal ulcers (GMUs) inWistar rats induced by indomethacin and diclofenac. Complex III at a dose of 1 mg/kg (0.1 mg of II ) reduced the number of indomethacin gastric ulcers by 46.4% ( p < 0.012) as compared with the control group and by 39.2% as compared with II at the same dose. The anti-ulcer activity of complex III at a dose of 1 mg/kg was 5.8 times higher than that of the initial prostaglandin at an equivalent dose (0.1 mg/kg) in a model of gastric ulcers caused by diclofenac.