Electrochemical oxidation and nanomolar detection of acetaminophen at a carbon-ceramic electrode modified by carbon nanotubes: a comparison between multi walled and single walled carbon nanotubes

Carbon-ceramic electrodes (CCE) modified with carbon nanotubes were prepared, and the electrochemical behavior towards acetaminophen (ACOP) was investigated using both a bare CCE and electrodes modified with either single walled carbon nanotubes (SWCNT) or multi walled carbon nanotubes (MWCNT) in an effort to understand which of them is the better choice in terms of electrocatalyzing the oxidation of ACOP, and thus for sensing it. The SWCNT are found to be the better material in significantly enhancing the oxidation peak current and improving the reversibility of the oxidation. Under optimal conditions, linearity between the oxidation peak current and the concentration of ACOP is obtained for the concentration range from 40 nM to 85 μM, with a detection limit of 25 nM. Finally, ACOP was successfully determined with the SWCNT modified electrode in pharmaceutical samples. [graphic removed]