Novel module and hub genes of distinctive breast cancer associated fibroblasts identified by weighted gene co‐expression network analysis

Background As abundant and heterogeneous stromal cells in tumor microenvironment, carcinoma-associated fibroblasts (CAFs) are critically involved in cancer progression. Methods To identify co-expression module and hub genes of distinctive breast CAFs, weighted gene co-expression network analysis (WG...

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Veröffentlicht in:	Breast cancer (Tokyo, Japan) Japan), 2020-09, Vol.27 (5), p.1017-1028
Hauptverfasser:	Xu, Yangguang, Zhang, Zhen, Zhang, Luoyan, Zhang, Chi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant treatment Analysis Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological response modifiers Biomarkers, Tumor - genetics Breast - pathology Breast - surgery Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - therapy Cancer Cancer Research Cancer-Associated Fibroblasts - drug effects Cancer-Associated Fibroblasts - pathology Carcinogenesis - drug effects Carcinogenesis - genetics Carcinogenesis - pathology Cell Line, Tumor Cells, Cultured Chemotherapy, Adjuvant Datasets as Topic Development and progression Disease Progression Drug Resistance, Neoplasm - genetics Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genes Genetic aspects Humans Interferon Mastectomy Medicine Medicine & Public Health Neoadjuvant Therapy - methods Oncology Original Article Primary Cell Culture Prognosis Surgery Surgical Oncology Tumor Microenvironment - drug effects Tumor Microenvironment - genetics
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Zusammenfassung:	Background As abundant and heterogeneous stromal cells in tumor microenvironment, carcinoma-associated fibroblasts (CAFs) are critically involved in cancer progression. Methods To identify co-expression module and hub genes of distinctive breast CAFs, weighted gene co-expression network analysis (WGCNA) was conducted based on the expression array results of CAFs from seven chemo-sensitive breast cancer (BC) patients and seven chemo-resistant ones before neo-adjuvant chemotherapy. Results A total of 4916 genes were included in WGCNA, and 12 modules were determined. Module-trait assay showed that the blue module (cor = 0.97, P
ISSN:	1340-6868 1880-4233
DOI:	10.1007/s12282-020-01101-3