Gut-derived bacterial toxins impair memory [CD4.sup.+] T cell mitochondrial function in HIV-1 infection

People living with HIV (PLWH) who are immune nonresponders (INRs) are at greater risk of comorbidity and mortality than are immune responders (IRs) who restore their [CD4.sup.+] T cell count after antiretroviral therapy (ART). INRs have low [CD4.sup.+] T cell counts (

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2022-05, Vol.132 (9)
Hauptverfasser:	Shive, Carey, Noel-Romas, Laura, Dobre, Mirela A, Korolevskaya, Larisa B, Sharma, Ashish Arunkumar, Ghannoum, Mahmoud A, Retuerto, Mauricio, Deeks, Steven G, Rodriguez, Benigno, Da Silva, Amanda Cabral, Chneim, Khader, Ferrari, Brian, Hunt, Peter P, Younes, Souheil-Antoine, Marconi, Vincent C, Jones, Dean P, Sekaly, Rafick-Pierre, Liu, Ken H, Saidakova, Evgeniya V, Sanchez, Gabriela Pacheco, Burgener, Adam D, Shmagel, Konstantin V
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial toxins Care and treatment CD4 lymphocytes Development and progression Health aspects HIV infection Immune response Immunologic memory Immunological research Microbiota (Symbiotic organisms) Physiological aspects
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Beschreibung
Zusammenfassung:	People living with HIV (PLWH) who are immune nonresponders (INRs) are at greater risk of comorbidity and mortality than are immune responders (IRs) who restore their [CD4.sup.+] T cell count after antiretroviral therapy (ART). INRs have low [CD4.sup.+] T cell counts (
ISSN:	0021-9738
DOI:	10.1172/JCI149571