N-TERMINAL PROHORMONE OF BRAIN NATRIURETIC PEPTIDE IN THE DIAGNOSIS AND MANAGEMENT OF PERSISTENT PULMONARY HYPERTENSION IN NEWBORNS/YENIDOGANLARDA PERSISTAN PULMONER HIPERTANSIYON TANISI VE YONETIMINDE N-TERMINAL PROHORMON BRAIN NATRIURETIK PEPTID
Objective: This study aimed to investigate the levels and utility of amino/N-terminal prohormone of brain natriuretic peptide (NT-proBNP) in the diagnosis of neonatal persistent pulmonary hypertension (PPHT). Materials and Methods: Infants born at [greater than or equal to] 34 weeks of gestation wer...
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| description | Objective: This study aimed to investigate the levels and utility of amino/N-terminal prohormone of brain natriuretic peptide (NT-proBNP) in the diagnosis of neonatal persistent pulmonary hypertension (PPHT). Materials and Methods: Infants born at [greater than or equal to] 34 weeks of gestation were included in this retrospective cross-sectional study. In total, 33 newborns diagnosed with PPHT were included in the patient group and 50 healthy newborns were included in the control group. Patient and control groups were compared in terms of plasma NT-proBNP levels measured in the umbilical cord (UC) and at 72 hours of life. Results: The NT-proBNP levels in UC and at 72 hours were significantly higher in neonates with PPHT compared to controls (p2760.5 pg/ml, sensitivity was 90.7%, and specificity was 96.6% (p1414 pg/ml, sensitivity was 95.9%, and specificity was 91.2% (p |
| doi_str_mv | 10.26650/IUITFD.957968 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A699755739</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A699755739</galeid><sourcerecordid>A699755739</sourcerecordid><originalsourceid>FETCH-LOGICAL-g679-af9f895e6e57c2096bd5ade3b346f7fc742a23f064bdd4329c8bd2eaffef961d3</originalsourceid><addsrcrecordid>eNptj81vwiAYxnvYkhnndWeSnau0FCpHtGjJKjQUt3gy_QDTxY9k7n_fdZi5ZMkMB3gf3t-T5wmCpwiOY0IwnIi1MItsTHFKyfQuGEQI4pAkCD0Eo_P5HUIY4yjCMBkEXzI0XK-EZAUotcqVXinJgVqAmWZCAsmMFmvNjZiDkpdGZBx42eQcZIItpapEBZjMwIpJtuQrLs0FLrn2H-YylevCWzK9AfnGy16rhJIXE8nfZkrLarLhUmRqyWTBdMZ-YSavLNcgFxeUeXTjWf8QlQCvHPjJR_PxfaxbTf61eLm2eAzuXb0_29H1HgZmwc08Dwu1FHNWhDuS0rB21E0ptsTitI0hJU2H686iBiXEpa5Nk7iOkYMkabouQTFtp00X29o56yiJOjQMnn9sd_XebvujO31-1O2hP7dbRihNMU4R9VvjG1v-dPbQt6ejdb3X_wDfJDaHrg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>N-TERMINAL PROHORMONE OF BRAIN NATRIURETIC PEPTIDE IN THE DIAGNOSIS AND MANAGEMENT OF PERSISTENT PULMONARY HYPERTENSION IN NEWBORNS/YENIDOGANLARDA PERSISTAN PULMONER HIPERTANSIYON TANISI VE YONETIMINDE N-TERMINAL PROHORMON BRAIN NATRIURETIK PEPTID</title><source>DOAJ Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><creator>Tufekci, Sinan ; Kizilca, Ozgur ; Aygun, Erhan</creator><creatorcontrib>Tufekci, Sinan ; Kizilca, Ozgur ; Aygun, Erhan</creatorcontrib><description><![CDATA[Objective: This study aimed to investigate the levels and utility of amino/N-terminal prohormone of brain natriuretic peptide (NT-proBNP) in the diagnosis of neonatal persistent pulmonary hypertension (PPHT). Materials and Methods: Infants born at [greater than or equal to] 34 weeks of gestation were included in this retrospective cross-sectional study. In total, 33 newborns diagnosed with PPHT were included in the patient group and 50 healthy newborns were included in the control group. Patient and control groups were compared in terms of plasma NT-proBNP levels measured in the umbilical cord (UC) and at 72 hours of life. Results: The NT-proBNP levels in UC and at 72 hours were significantly higher in neonates with PPHT compared to controls (p<0.01). For the diagnosis of PPHT, UC NT-proBNP cut-off value was >2760.5 pg/ml, sensitivity was 90.7%, and specificity was 96.6% (p<0.01). For NT-proBNP at 72 hours, the cut-off value was >1414 pg/ml, sensitivity was 95.9%, and specificity was 91.2% (p<0.01). The mean UC NT-proBNP levels were 1094.7 [+ or -] 603 pg/ml and mean NT-proBNP levels at 72 hours were 875.7 [+ or -] 423 pg/ml in the control group. Conclusion: NT-proBNP levels are high during the initial days of life. They are useful in the diagnosis and follow-up of PPHT in newborns with hypoxemic respiratory failure and high fraction of inspired oxygen (FiO2) requirement, especially in cases where transthoracic echocardiography (TTE) cannot be performed. Keywords: NT-proBNP, persistent pulmonary hypertension, newborn, umbilical cord, echocardiography Amac: Bu calismada, beyin natriuretik peptidinin (NT-proBNP) amino/N-terminal prohormonunun duzeylerinin ve yenidogan kalici pulmoner hipertansiyon (PPHT) tanisinda kullaniminin arastirilmasi amaclandi. Gerec ve Yontem: Bu retrospektif kesitsel calismaya [greater than or equal to] 34 gebelik haftasinda dogan bebekler dahil edildi. Hasta grubuna PPHT tanisi konan 33 yenidogan, kontrol grubuna ise 50 saglikli yenidogan alindi. Hasta ve kontrol gruplari, gobek kordonunda (UC) ve 72 saatlik yasamda olculen plazma NT-proBNP seviyeleri acisindan karsilastirildi. Bulgular: UC'da ve 72. saatte NT-proBNP seviyeleri, kontrollere kiyasla PPHT'lu yenidoganlarda anlamli derecede yuksekti (p<0,01). PPHT tanisi icin UC NT-proBNP esik degeri >2760,5 pg/ml, duyarlilik %90,7 ve ozgulluk %96,6 (p<0,01) idi. Yetmisikinci saatte NT-proBNP icin esik degeri >1414 pg/ml, duyarlilik %95,9 ve ozgulluk %91,2 idi (p<0,01). Kontrol grubunda ortalama UC NT-proBNP seviyeleri 1094,7 [+ or -] 603 pg/ml ve 72 saatte ortalama NT-proBNP seviyeleri 875,7 [+ or -] 423 pg/ml idi. Sonuc: NT-proBNP seviyeleri yasamin ilk gunlerinde yuksektir. Ozellikle transtorasik ekokardiyografinin (TTE) yapilamadigi durumlarda, hipoksemik solunum yetmezligi ve inspire edilen oksijen fraksiyonu (FiO2) gereksinimi yuksek olan yenidoganlarda PPHT tani ve takibinde faydalidir. Anahtar Kelimeler: NT-proBNP, persistan pulmoner hipertansiyon, yenidogan, gobek kordonu, ekokardiyografi]]></description><identifier>ISSN: 1305-6433</identifier><identifier>DOI: 10.26650/IUITFD.957968</identifier><language>eng</language><publisher>AVES</publisher><subject>Brain natriuretic peptide ; Diagnosis ; Diseases ; Health aspects ; Infants (Newborn) ; Measurement ; Pediatric research ; Pulmonary hypertension</subject><ispartof>İstanbul Tıp Fakültesi dergisi = Journal of the Istanbul Faculty of Medicine, 2022-06, Vol.85 (2), p.228</ispartof><rights>COPYRIGHT 2022 AVES</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,866,27931,27932</link.rule.ids></links><search><creatorcontrib>Tufekci, Sinan</creatorcontrib><creatorcontrib>Kizilca, Ozgur</creatorcontrib><creatorcontrib>Aygun, Erhan</creatorcontrib><title>N-TERMINAL PROHORMONE OF BRAIN NATRIURETIC PEPTIDE IN THE DIAGNOSIS AND MANAGEMENT OF PERSISTENT PULMONARY HYPERTENSION IN NEWBORNS/YENIDOGANLARDA PERSISTAN PULMONER HIPERTANSIYON TANISI VE YONETIMINDE N-TERMINAL PROHORMON BRAIN NATRIURETIK PEPTID</title><title>İstanbul Tıp Fakültesi dergisi = Journal of the Istanbul Faculty of Medicine</title><description><![CDATA[Objective: This study aimed to investigate the levels and utility of amino/N-terminal prohormone of brain natriuretic peptide (NT-proBNP) in the diagnosis of neonatal persistent pulmonary hypertension (PPHT). Materials and Methods: Infants born at [greater than or equal to] 34 weeks of gestation were included in this retrospective cross-sectional study. In total, 33 newborns diagnosed with PPHT were included in the patient group and 50 healthy newborns were included in the control group. Patient and control groups were compared in terms of plasma NT-proBNP levels measured in the umbilical cord (UC) and at 72 hours of life. Results: The NT-proBNP levels in UC and at 72 hours were significantly higher in neonates with PPHT compared to controls (p<0.01). For the diagnosis of PPHT, UC NT-proBNP cut-off value was >2760.5 pg/ml, sensitivity was 90.7%, and specificity was 96.6% (p<0.01). For NT-proBNP at 72 hours, the cut-off value was >1414 pg/ml, sensitivity was 95.9%, and specificity was 91.2% (p<0.01). The mean UC NT-proBNP levels were 1094.7 [+ or -] 603 pg/ml and mean NT-proBNP levels at 72 hours were 875.7 [+ or -] 423 pg/ml in the control group. Conclusion: NT-proBNP levels are high during the initial days of life. They are useful in the diagnosis and follow-up of PPHT in newborns with hypoxemic respiratory failure and high fraction of inspired oxygen (FiO2) requirement, especially in cases where transthoracic echocardiography (TTE) cannot be performed. Keywords: NT-proBNP, persistent pulmonary hypertension, newborn, umbilical cord, echocardiography Amac: Bu calismada, beyin natriuretik peptidinin (NT-proBNP) amino/N-terminal prohormonunun duzeylerinin ve yenidogan kalici pulmoner hipertansiyon (PPHT) tanisinda kullaniminin arastirilmasi amaclandi. Gerec ve Yontem: Bu retrospektif kesitsel calismaya [greater than or equal to] 34 gebelik haftasinda dogan bebekler dahil edildi. Hasta grubuna PPHT tanisi konan 33 yenidogan, kontrol grubuna ise 50 saglikli yenidogan alindi. Hasta ve kontrol gruplari, gobek kordonunda (UC) ve 72 saatlik yasamda olculen plazma NT-proBNP seviyeleri acisindan karsilastirildi. Bulgular: UC'da ve 72. saatte NT-proBNP seviyeleri, kontrollere kiyasla PPHT'lu yenidoganlarda anlamli derecede yuksekti (p<0,01). PPHT tanisi icin UC NT-proBNP esik degeri >2760,5 pg/ml, duyarlilik %90,7 ve ozgulluk %96,6 (p<0,01) idi. Yetmisikinci saatte NT-proBNP icin esik degeri >1414 pg/ml, duyarlilik %95,9 ve ozgulluk %91,2 idi (p<0,01). Kontrol grubunda ortalama UC NT-proBNP seviyeleri 1094,7 [+ or -] 603 pg/ml ve 72 saatte ortalama NT-proBNP seviyeleri 875,7 [+ or -] 423 pg/ml idi. Sonuc: NT-proBNP seviyeleri yasamin ilk gunlerinde yuksektir. Ozellikle transtorasik ekokardiyografinin (TTE) yapilamadigi durumlarda, hipoksemik solunum yetmezligi ve inspire edilen oksijen fraksiyonu (FiO2) gereksinimi yuksek olan yenidoganlarda PPHT tani ve takibinde faydalidir. Anahtar Kelimeler: NT-proBNP, persistan pulmoner hipertansiyon, yenidogan, gobek kordonu, ekokardiyografi]]></description><subject>Brain natriuretic peptide</subject><subject>Diagnosis</subject><subject>Diseases</subject><subject>Health aspects</subject><subject>Infants (Newborn)</subject><subject>Measurement</subject><subject>Pediatric research</subject><subject>Pulmonary hypertension</subject><issn>1305-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptj81vwiAYxnvYkhnndWeSnau0FCpHtGjJKjQUt3gy_QDTxY9k7n_fdZi5ZMkMB3gf3t-T5wmCpwiOY0IwnIi1MItsTHFKyfQuGEQI4pAkCD0Eo_P5HUIY4yjCMBkEXzI0XK-EZAUotcqVXinJgVqAmWZCAsmMFmvNjZiDkpdGZBx42eQcZIItpapEBZjMwIpJtuQrLs0FLrn2H-YylevCWzK9AfnGy16rhJIXE8nfZkrLarLhUmRqyWTBdMZ-YSavLNcgFxeUeXTjWf8QlQCvHPjJR_PxfaxbTf61eLm2eAzuXb0_29H1HgZmwc08Dwu1FHNWhDuS0rB21E0ptsTitI0hJU2H686iBiXEpa5Nk7iOkYMkabouQTFtp00X29o56yiJOjQMnn9sd_XebvujO31-1O2hP7dbRihNMU4R9VvjG1v-dPbQt6ejdb3X_wDfJDaHrg</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Tufekci, Sinan</creator><creator>Kizilca, Ozgur</creator><creator>Aygun, Erhan</creator><general>AVES</general><scope/></search><sort><creationdate>20220601</creationdate><title>N-TERMINAL PROHORMONE OF BRAIN NATRIURETIC PEPTIDE IN THE DIAGNOSIS AND MANAGEMENT OF PERSISTENT PULMONARY HYPERTENSION IN NEWBORNS/YENIDOGANLARDA PERSISTAN PULMONER HIPERTANSIYON TANISI VE YONETIMINDE N-TERMINAL PROHORMON BRAIN NATRIURETIK PEPTID</title><author>Tufekci, Sinan ; Kizilca, Ozgur ; Aygun, Erhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g679-af9f895e6e57c2096bd5ade3b346f7fc742a23f064bdd4329c8bd2eaffef961d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Brain natriuretic peptide</topic><topic>Diagnosis</topic><topic>Diseases</topic><topic>Health aspects</topic><topic>Infants (Newborn)</topic><topic>Measurement</topic><topic>Pediatric research</topic><topic>Pulmonary hypertension</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tufekci, Sinan</creatorcontrib><creatorcontrib>Kizilca, Ozgur</creatorcontrib><creatorcontrib>Aygun, Erhan</creatorcontrib><jtitle>İstanbul Tıp Fakültesi dergisi = Journal of the Istanbul Faculty of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tufekci, Sinan</au><au>Kizilca, Ozgur</au><au>Aygun, Erhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-TERMINAL PROHORMONE OF BRAIN NATRIURETIC PEPTIDE IN THE DIAGNOSIS AND MANAGEMENT OF PERSISTENT PULMONARY HYPERTENSION IN NEWBORNS/YENIDOGANLARDA PERSISTAN PULMONER HIPERTANSIYON TANISI VE YONETIMINDE N-TERMINAL PROHORMON BRAIN NATRIURETIK PEPTID</atitle><jtitle>İstanbul Tıp Fakültesi dergisi = Journal of the Istanbul Faculty of Medicine</jtitle><date>2022-06-01</date><risdate>2022</risdate><volume>85</volume><issue>2</issue><spage>228</spage><pages>228-</pages><issn>1305-6433</issn><abstract><![CDATA[Objective: This study aimed to investigate the levels and utility of amino/N-terminal prohormone of brain natriuretic peptide (NT-proBNP) in the diagnosis of neonatal persistent pulmonary hypertension (PPHT). Materials and Methods: Infants born at [greater than or equal to] 34 weeks of gestation were included in this retrospective cross-sectional study. In total, 33 newborns diagnosed with PPHT were included in the patient group and 50 healthy newborns were included in the control group. Patient and control groups were compared in terms of plasma NT-proBNP levels measured in the umbilical cord (UC) and at 72 hours of life. Results: The NT-proBNP levels in UC and at 72 hours were significantly higher in neonates with PPHT compared to controls (p<0.01). For the diagnosis of PPHT, UC NT-proBNP cut-off value was >2760.5 pg/ml, sensitivity was 90.7%, and specificity was 96.6% (p<0.01). For NT-proBNP at 72 hours, the cut-off value was >1414 pg/ml, sensitivity was 95.9%, and specificity was 91.2% (p<0.01). The mean UC NT-proBNP levels were 1094.7 [+ or -] 603 pg/ml and mean NT-proBNP levels at 72 hours were 875.7 [+ or -] 423 pg/ml in the control group. Conclusion: NT-proBNP levels are high during the initial days of life. They are useful in the diagnosis and follow-up of PPHT in newborns with hypoxemic respiratory failure and high fraction of inspired oxygen (FiO2) requirement, especially in cases where transthoracic echocardiography (TTE) cannot be performed. Keywords: NT-proBNP, persistent pulmonary hypertension, newborn, umbilical cord, echocardiography Amac: Bu calismada, beyin natriuretik peptidinin (NT-proBNP) amino/N-terminal prohormonunun duzeylerinin ve yenidogan kalici pulmoner hipertansiyon (PPHT) tanisinda kullaniminin arastirilmasi amaclandi. Gerec ve Yontem: Bu retrospektif kesitsel calismaya [greater than or equal to] 34 gebelik haftasinda dogan bebekler dahil edildi. Hasta grubuna PPHT tanisi konan 33 yenidogan, kontrol grubuna ise 50 saglikli yenidogan alindi. Hasta ve kontrol gruplari, gobek kordonunda (UC) ve 72 saatlik yasamda olculen plazma NT-proBNP seviyeleri acisindan karsilastirildi. Bulgular: UC'da ve 72. saatte NT-proBNP seviyeleri, kontrollere kiyasla PPHT'lu yenidoganlarda anlamli derecede yuksekti (p<0,01). PPHT tanisi icin UC NT-proBNP esik degeri >2760,5 pg/ml, duyarlilik %90,7 ve ozgulluk %96,6 (p<0,01) idi. Yetmisikinci saatte NT-proBNP icin esik degeri >1414 pg/ml, duyarlilik %95,9 ve ozgulluk %91,2 idi (p<0,01). Kontrol grubunda ortalama UC NT-proBNP seviyeleri 1094,7 [+ or -] 603 pg/ml ve 72 saatte ortalama NT-proBNP seviyeleri 875,7 [+ or -] 423 pg/ml idi. Sonuc: NT-proBNP seviyeleri yasamin ilk gunlerinde yuksektir. Ozellikle transtorasik ekokardiyografinin (TTE) yapilamadigi durumlarda, hipoksemik solunum yetmezligi ve inspire edilen oksijen fraksiyonu (FiO2) gereksinimi yuksek olan yenidoganlarda PPHT tani ve takibinde faydalidir. Anahtar Kelimeler: NT-proBNP, persistan pulmoner hipertansiyon, yenidogan, gobek kordonu, ekokardiyografi]]></abstract><pub>AVES</pub><doi>10.26650/IUITFD.957968</doi></addata></record> |
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| identifier | ISSN: 1305-6433 |
| ispartof | İstanbul Tıp Fakültesi dergisi = Journal of the Istanbul Faculty of Medicine, 2022-06, Vol.85 (2), p.228 |
| issn | 1305-6433 |
| language | eng |
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| subjects | Brain natriuretic peptide Diagnosis Diseases Health aspects Infants (Newborn) Measurement Pediatric research Pulmonary hypertension |
| title | N-TERMINAL PROHORMONE OF BRAIN NATRIURETIC PEPTIDE IN THE DIAGNOSIS AND MANAGEMENT OF PERSISTENT PULMONARY HYPERTENSION IN NEWBORNS/YENIDOGANLARDA PERSISTAN PULMONER HIPERTANSIYON TANISI VE YONETIMINDE N-TERMINAL PROHORMON BRAIN NATRIURETIK PEPTID |
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