KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer

KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer

KIFs have been reported to play a critical role in a variety of tumors, and KIF20B is a protein in KFIs. In this research, KIF20B was highly expressed in the GEO database and our hospital’s data, and high expression of KIF20B suggested poor prognosis. We detect the expression of KIF20B in pancreatic...

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Veröffentlicht in:Journal of oncology 2021-09, Vol.2021, p.1-11, Article 5572402
Hauptverfasser: Chen, Jing, Zhao, Cui-Cui, Chen, Fei-Ran, Feng, Guo-Wei, Luo, Fei, Jiang, Tao
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine triphosphatase
Antibodies
Cell cycle
Cell growth
Health aspects
Immunohistochemistry
Life Sciences & Biomedicine
Medical prognosis
Methylene blue
Oncology
Pancreatic cancer
Plasmids
Prognosis
Proteins
Science & Technology
Software
Tumors
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Zusammenfassung:KIFs have been reported to play a critical role in a variety of tumors, and KIF20B is a protein in KFIs. In this research, KIF20B was highly expressed in the GEO database and our hospital’s data, and high expression of KIF20B suggested poor prognosis. We detect the expression of KIF20B in pancreatic cancer and adjacent normal tissues using immunohistochemistry. Knockdown of KIF20B in pancreatic cancer cell lines, PANC-1 and BxPC-3 cells, inhibited cell proliferation which are detected by colony formation assays, CCK8, and western bolt of Ki-67 and PCNA. Xenograft assay showed a similar result in vivo. KIF20B is a potential therapeutic target in pancreatic cancer.
ISSN:1687-8450
1687-8450
DOI:10.1155/2021/5572402