Analgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance

Sophora viciifolia Hance is an edible plant used in traditional Chinese medicine. Sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in Sophora viciifolia Hance. Here, we study the analgesic and anti-inflammatory effects, as well as the acute toxicity...

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Veröffentlicht in:	BioMed research international 2021, Vol.2021, p.8893563-7, Article 8893563
Hauptverfasser:	Wang, F. L., Wang, H., Wang, J. H., Wang, D. X., Gao, Y., Yang, B., Yang, H. J., Ji, Y. B., Xin, G. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Acids Acute toxicity Alkaloids - metabolism Alkaloids - pharmacology Analgesics Analgesics - metabolism Analgesics - pharmacology Analysis Animals Animals, Outbred Strains Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Anti-inflammatory drugs Beans Biotechnology & Applied Microbiology Calcium chloride Care and treatment Cytokines Dosage and administration Drug dosages Drugs, Chinese Herbal - therapeutic use Dye penetrants Edema Edema - drug therapy Health aspects Herbal medicine Identification and classification Inflammation Inflammation - drug therapy Interleukin 6 Interleukins Laboratory animals Latency Legumes Life Sciences & Biomedicine Male Medicinal plants Medicine, Chinese Medicine, Chinese Traditional - methods Medicine, Research & Experimental Mice Mimosaceae NF-kappa B Nitric oxide Nutritional aspects Pain Pain - drug therapy Pain - physiopathology Pharmaceuticals Plant Extracts - pharmacology Prostaglandin E2 Research & Experimental Medicine Science & Technology Sophora - metabolism Sophora viciifolia Statistical analysis Toxicity Traditional Chinese medicine Tumor necrosis factor-TNF Verapamil Writhing reaction Xylene
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Zusammenfassung:	Sophora viciifolia Hance is an edible plant used in traditional Chinese medicine. Sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in Sophora viciifolia Hance. Here, we study the analgesic and anti-inflammatory effects, as well as the acute toxicity of sophocarpine from Sophora viciifolia Hance in mice. Sophocarpine (20, 40, and 80 mg/kgbw) significantly prolonged the delay period before a hot plate reaction occurred (all P
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2021/8893563