The effects of topical liposomal resveratrol on incisional and excisional wound healing process/Topikal lipozomal resveratrolun insizyonal ve eksizyonal yara iyilesme surecine etkileri

Background and Design: The objective of this study was to investigate the wound healing activity of different concentrations of liposomal trans-resveratrol formulations on incisional and excisional wounds in rats. Materials and Methods: The wound healing effect was tested by an excisional and incisional wound model. Wound closure was measured for 12 days. On the 12th day of the study, maximal load, maximum stress, stress, and % of elongation values were evaluated in the incisional wound. In addition, angiogenesis, granulation tissue thickness, epidermal and dermal regeneration values, and macroscopic photographic analyses were evaluated in the excisional wound. Results: When the wound tissue surface healing rates were evaluated, similar effects were observed at the end of the 10th and 12th days between the 5% Res group and the commercial product containing 1% Centella asiatica extract used as the reference molecule. Histological evaluation showed that 1% Res and 5% Res groups induced significant wound healing activity compared to the control group. Furthermore, 1% Res and 5% Res groups increased wound healing rates by promoting granulation tissue, epidermal, and dermal regeneration as well as angiogenesis. Conclusion: Liposomal formulations containing 1% and 5% resveratrol were found to have positive effects on the healing process, both on excisional and incisional wound tissues. Keywords: Resveratol, liposome, incisional wound, excisional wound, axial tensile-elongation tests Amac: Bu calismanin amaci, sicanlarda insizyonel ve eksizyonel yaralar uzerine farkli konsantrasyonlarda hazirlanmis lipozomal trans-resveratrol formulasyonlarinin yara iyilesme aktivitesi uzerine etkinligini arastirmaktir. Gerec ve Yontem: Yara iyilesme etkisi, eksizyonel ve insizyonel yara modeli kullanilarak test edildi. Yara yuzey alanlari 12 gun suresince olculdu. Calismanin 12. gununde, insizyonel yaralarda maksimum yuk, maksimum stres, gerginlik (strain) ve % uzama degerleri degerlendirildi. Ek olarak, eksizyonel yaralarda anjiyogenez, granulasyon dokusu kalinligi, epidermal ve dermal rejenerasyon degerleri ve makroskopik fotograf analizleri degerlendirildi. Bulgular: Yara dokusu yuzey iyilesme oranlari degerlendirildiginde, %5 Res grubu ile referans molekul olarak kullanilan 1% Centella asiatica ekstresi arasinda 10. ve 12. gunlerde benzer etkiler gozlendi. Histolojik degerlendirme, %1 Res ve %5 Res gruplarinin kontrol grubuna kiyasla anlamli yara iyilesme aktivitesi olusturd