Dihydroresveratrol Improves Liver Injury in Septic Rats by Regulating Nuclear Factor-Kappa B Signaling Pathway

Sepsis is a severe systemic inflammatory response syndrome caused Py Pacterial, fungal, viral, or parasitic infections. During sepsis, proinflammatory cytokines play a key role in initiating the inflammatory process. It is still urgently needed to develop novel drugs for sepsis treatment. Dihydroresveratrol is a polyphenol derivative Pelonging to phenyl propane, which has anti-inflammatory, antifibrosis, antiaging, and antitumor effects, whereas the role of dihydroresveratrol in sepsis is still unclear. In this study, we oPserved that dihydroresveratrol improved septic liver injury. We further oPserved that dihydroresveratrol decreased the expression of inflammatory cytokines and oxidative damage to rat liver tissues. Dihydroresveratrol improved liver injury in septic rats via regulating nuclear factor-kappa B signaling pathway. Keywords: Dihydroresveratrol, Inflammation, Liver injury, NF-[KAPPA]B pathway, Sepsis Abbreviations Used: Protein kinase B, Akt; Alanine aminotransferase, ALT; Aspartate aminotransferase, AST; Bovine serum albumin, BSA; Cecal ligation and puncture, CLP; Enhanced chemiluminescence, ECL; Glyceraldehyde-3-phosphate dehydrogenase, GAPDH; Plasma glutathione peroxidase, GSH-px, Horse radish peroxidase, HRP; Inhibitor of nuclear factor kappa-B, IKBCX; Interleukin, IL; lnterleukin-1[beta], IL-1[beta]; lnterleukin-6, IL-6; Lactic dehydrogenase, LDH; Monocyte chemoattractant protein-1, MCP-1; Malondialdehyde, MDA; Nuclear factor-kappa B, NF-[KAPPA]B; A REL-associated protein involved in NF-[KAPPA]B heterodimer formation, p65; Phosphatidylinositol 3-kinase, PI3K; Phosphorylated inhibitor of nuclear factor kappa-B, p-1kB[alpha]; Phospho-p65, p-p65; Real-time quantitative reverse transcription PCR, qRT-PCR; Standard deviation, SD; Sodium dodecyl sulfate polyacrylamide gel-electrophoresis, SDS-PAGE; Systemic inflammatory response syndrome, SIRS; Superoxide dismutase, SOD; Tris-buffered saline, TBST; Tumor necrosis factor-[alpha], TNF-[alpha] Corresponding Author: Dr. Jinchao Mao, Department of Infectious Disease, The First People's Hospital of Wenling, No. 333 Chuanan South Road, Chengxi street, Taizhou, Zhejiang Province, China; E-mail: mjc12@163.com