An age-stratified serosurvey against purified Salmonella enterica serovar Typhi antigens in the Lao People's Democratic Republic

The epidemiology of typhoid fever in Lao People`s Democratic Republic is poorly defined. Estimating the burden of typhoid fever in endemic countries is complex due to the cost and limitations of population-based surveillance; serological approaches may be a more cost-effective alternative. ELISAs we...

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Veröffentlicht in:	PLoS neglected tropical diseases 2021-12, Vol.15 (12)
Hauptverfasser:	Hefele, Lisa, Black, Antony P, Van Tan, Trinh, Tri Minh, Nguyen, Duc Hoang, Nguyen, Virachith, Siriphone, Muller, Claude P, Hübschen, Judith M, Russell, Paula, Bartholdson Scott, Josefin, Ngoc Minh, Chau Nguyen, Thieu Nga, Tran Vu, Baker, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Demographic aspects Risk factors Salmonella typhosa Statistics Typhoid fever
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Zusammenfassung:	The epidemiology of typhoid fever in Lao People`s Democratic Republic is poorly defined. Estimating the burden of typhoid fever in endemic countries is complex due to the cost and limitations of population-based surveillance; serological approaches may be a more cost-effective alternative. ELISAs were performed on 937 serum samples (317 children and 620 adults) from across Lao PDR to measure IgG antibody titers against Vi polysaccharide and the experimental protein antigens, CdtB and HlyE. We measured the significance of the differences between antibody titers in adults and children and fitted models to assess the relationship between age and antibody titers. The median IgG titres of both anti-HylE and CdtB were significantly higher in children compared to adults (anti-HylE; 351.7 ELISA Units (EU) vs 198.1 EU, respectively; p
ISSN:	1935-2727
DOI:	10.1371/journal.pntd.0010017