Son Iki Yilda Bursa Uludag Üniversitesi Tip Fakültesi'nde Görülen Toxoplasma gondii Serolojik Prevalansi/Serological Prevalence of Toxoplasma gondii in Faculty of Medicine of Bursa Uludag University During 2016-2018

Amaç: Bu çalismada, 24 aylik sürede (Ocak 2017-Aralik 2018) Bursa Uludag Üniversitesi Tip Fakültesi Hastanesine basvuran hastalarin seroloji laboratuvarinda çalisilan Toxoplasma gondii IgM, Toxoplasma gondii IgG ve IgG avidite test sonuçlarinin irdelenmesi amaçlanmistir. Yöntemler: Hastalarin serum örneklerinde T. gondii IgM ve IgG antikorlari ve T. gondii IgG avidite testleri, VIDAS otomatize sisteminde (BioMérieux, France) üretici firmanin önerileri dogrultusunda çalisilmistir. Bulgular: T. gondii IgM antikorlari %1,7 (101/6104) oraninda saptanirken, T. gondii IgG antikorlari %37,9 (1,149/3024) oraninda bulunmustur. Dogurganlik yas grubundaki kadinlarda T. gondii IgG seropozitifligi %31,5 oraninda saptanmistir. T. gondii IgG avidite testi, dogurgan yas grubunda 191 kadinin 134'ünde (%70,1) yüksek, 29'unda (%15,2) düsük saptanmistir. Sonuç: Dogurgan çagdaki kadinlarda toksoplasma serolojisinin taranmasinin ve tanisinin önemli oldugu düsünülmektedir. Çalisma sonuçlarinin T. gondii enfeksiyonuna karsi alinacak optimal kontrol ve önlemlerde yardimci olabilecegi kanisina varilmistir. Anahtar Kelimeler: Toxoplasma gondii, seroprevalans, Bursa Objective: This study aimed to retrospectively investigate Toxoplasma gondii IgG and IgM distribution and IgG avidity in serum samples with suspected toxoplasmosis in the medical microbiology serology laboratory of Faculty of Medicine Hospital at Bursa Uludag University over a 24-month period (January 2016 to December 2018). Methods: An enzyme-linked fluorescent assay using the VIDAS automated analyzer (BioMérieux, France) was used to determine T. gondii IgM antibodies, T. gondii IgG antibodies, and T. gondii IgG avidity. Results: The T. gondii IgM antibody positivity was found to be 1.7% (101/6104), whereas the T. gondii IgG antibody positivity was 37.9% (1.149/3024). The seropositivity of T. gondii IgG was 31.5% in women belonging to the childbearing age group. In this group, T. gondii IgG high and low avidity rates were 70.1% (134/191) and 15.2% (29/191), respectively. Conclusion: Screening and diagnosis of toxoplasma serology in women of childbearing age is important. The results of this study may be useful for designing optimal control and preventive measures against T. gondii infection. Keywords: Toxoplasma gondii, seroprevalence, Bursa