Clinical significance of soluble form of poliovirus receptor in newly diagnosed follicular lymphoma

Background Follicular lymphoma (FL) remains an incurable malignancy with heterogeneous clinical outcomes that necessitate a better understanding of disease biology. Poliovirus receptor (PVR/CD155) is markedly overexpressed in several human malignant tumors and it has a unique dual oncoimmunoregulatory role. However, the role of the soluble form of PVR (sCD155) in FL has not been fully elucidated. Methods Soluble PVR(sCD155) were measured in the sera of 50 patients newly diagnosed with FL by sandwich enzyme-linked immunosorbent assay and compared with those of 20 healthy control participants. Moreover, we evaluated its association with the clinicopathological parameters as well as response to chemotherapy in such patients. Results Pretreatment level of sCD155 was significantly higher in patients with FL than in control participants (P