Progesterone Receptor Together with PKC[alpha] Expression as Prognostic Factors for Astrocytomas Malignancy

Introduction: Astrocytomas are the most common and aggressive primary brain tumors, and they are classified according to the degree of malignancy on a scale of I to IV, in which grade I is the least malignant and grade IV the highest. Many factors are related to astrocytomas progression as progester...

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Veröffentlicht in:OncoTargets and therapy 2021-06, Vol.14, p.3757
Hauptverfasser: Arcos-Montoya, Denisse, Wegman-Ostrosky, Talia, Mejia-Perez, Sonia, De la Fuente-Granada, Marisol, Camacho-Arroyo, Ignacio, Garcia-Carranca, Alejandro, Velasco-Velazquez, Marco A, Manjarrez-Marmolejo, Joaquin, Gonzalez-Arenas, Aliesha
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Sprache:eng
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Zusammenfassung:Introduction: Astrocytomas are the most common and aggressive primary brain tumors, and they are classified according to the degree of malignancy on a scale of I to IV, in which grade I is the least malignant and grade IV the highest. Many factors are related to astrocytomas progression as progesterone receptor (PR), whose transcriptional activity could be regulated by phosphorylation by protein kinase C alpha (PKC[alpha]) at the residue Ser400. Our aim was to investigate if PR phosphorylation together with PKC[alpha] expression could be used as a prognostic factor for astrocytomas malignancy. Methods: By immunofluorescence, we detected the content of PKC[alpha], PR and its phosphorylation at Ser400 in 46 biopsies from Mexican patients with different astrocytoma malignancy grades; by bioinformatic tools using TCGA data, we evaluated the expression of PR and PKC[alpha] mRNA according to astrocytoma malignancy grades. For all statistical analyses, significance was p
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S280314