Progesterone Receptor Together with PKC[alpha] Expression as Prognostic Factors for Astrocytomas Malignancy
Introduction: Astrocytomas are the most common and aggressive primary brain tumors, and they are classified according to the degree of malignancy on a scale of I to IV, in which grade I is the least malignant and grade IV the highest. Many factors are related to astrocytomas progression as progester...
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Veröffentlicht in: | OncoTargets and therapy 2021-06, Vol.14, p.3757 |
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Sprache: | eng |
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Zusammenfassung: | Introduction: Astrocytomas are the most common and aggressive primary brain tumors, and they are classified according to the degree of malignancy on a scale of I to IV, in which grade I is the least malignant and grade IV the highest. Many factors are related to astrocytomas progression as progesterone receptor (PR), whose transcriptional activity could be regulated by phosphorylation by protein kinase C alpha (PKC[alpha]) at the residue Ser400. Our aim was to investigate if PR phosphorylation together with PKC[alpha] expression could be used as a prognostic factor for astrocytomas malignancy. Methods: By immunofluorescence, we detected the content of PKC[alpha], PR and its phosphorylation at Ser400 in 46 biopsies from Mexican patients with different astrocytoma malignancy grades; by bioinformatic tools using TCGA data, we evaluated the expression of PR and PKC[alpha] mRNA according to astrocytoma malignancy grades. For all statistical analyses, significance was p |
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ISSN: | 1178-6930 1178-6930 |
DOI: | 10.2147/OTT.S280314 |