Recent advances in research on aspartate [beta]-hydroxylase in pancreatic cancer: A brief update

Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate [beta]-hydroxylase (ASPH) is a type II transmembrane protein and the member of a-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. In this review, we briefly summarize the possible mechanisms of action of ASPH in PC and recent progress in the therapeutic approaches targeting ASPH. KEY WORDS: Aspartate [beta]-hydroxylase; pancreatic cancer; Notch signaling pathway; Mitochondrial DNA; NK cell DOI: