The impact of chirality on the analysis of alkaloids in plant

Most of the alkaloids are chiral compounds and are clinically administered as the racemic mixture, even though its enantiomers have been known to exert different pharmacological activity. The determination of the enantiomeric composition of alkaloid-containing plants is subject to severe attention f...

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Veröffentlicht in:Farmacija 2021-09, Vol.68 (3), p.643-656
Hauptverfasser: Nguyen, Ngoc-Van Thi, Nguyen, Kim-Ngan Huynh, Nguyen, Kien Trung, Kim, Kyeong Ho, Aboul-Enein, Hassan Y
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Sprache:eng
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Zusammenfassung:Most of the alkaloids are chiral compounds and are clinically administered as the racemic mixture, even though its enantiomers have been known to exert different pharmacological activity. The determination of the enantiomeric composition of alkaloid-containing plants is subject to severe attention from pharmacological and toxicological points of view. This review gives an overview of the chiral analysis of alkaloids that were used in theoretical studies and applications for plants in recent years.
ISSN:0428-0296
2603-557X
DOI:10.3897/pharmacia.68.e71101