Glyoxalase 1 and protein kinase C[lambda] as potential therapeutic targets for late-stage breast cancer

Cancer cells upregulate the expression levels of glycolytic enzymes in order to reach the increased glycolysis required. One such upregulated glycolytic enzyme is glyoxalase 1 (GLO 1), which catalyzes the conversion of toxic methylglyoxal to nontoxic S-D-lactoylglutathione. Protein kinase C[lambda] (PKC[lambda]) is also upregulated in various types of cancer and is involved in cancer progression. In the present study, the association between enhanced glycolysis and PKC[lambda] in breast cancer was investigated. In human breast cancer, high GLO 1 expression was associated with high PKC[lambda] expression at the protein (P