The Clinical Value of Computed Tomography -Guided [.sup.125]I Brachytherapy for Locally Advanced Non-Small Cell Lung Cancer After Progression of Concurrent Radiochemotherapy

Purpose: To further evaluate the efficacy and safety of computed tomography (CT)-guided iodine 125 ([.sup.125]I) brachytherapy to treat locally advanced non-small cell lung cancer (NSCLC) after progression of concurrent radiochemotherapy (CCRT). Methods: This study obtained written consent from all patients and was approved by our institution. From January 2006 to June 2018, 210 NSCLC patients (progression of first-line CCRT) were retrospectively recruited and then divided into two groups. A total of 116 patients were given CT-guided [.sup.125]I brachytherapy and second-line chemotherapy (group A), and 94 were treated with second-line chemotherapy alone (group B). Results: In group A, local response rate (LRR) within 3 years was significantly better (P