Clinical study of a particle-integrated esophageal covered stent and hyperbaric oxygen in the treatment of advanced esophageal cancer

Objective: this study aimed to investigate the clinical efficacy and feasibility of the treatment of advanced esophageal cancer with a combination of a ([.sup.125]l) particle-integrated esophageal covered stent and hyperbaric oxygen. Methods: forty-five patients with advanced esophageal cancer were enrolled and were randomly divided into two groups: a treatment group and a control group. Patients in the treatment group were treated with a ([.sup.125]l) particle-integrated esophageal covered stent and hyperbaric oxygen, while patients in the control group were treated with a ([.sup.125]l) particle-integrated esophageal covered stent. The clinical effects and long-term survival time of the two groups were observed. Results: in the treatment group, the complete remission (CR) rate and partial remission (PR) rate of local lesions Qi-Zhou Zhang and Guo-liang Li contributed equally to this study. Acknowledgements: the authors would like to acknowledge the hard and dedicated work of all the staff that implemented the intervention and evaluation components of the study. Funding: this study was funded by the Project of Foshan Science and Technology Bureau (project no. 2018AB000102). The funding body had no role in the design of the study the collection, analysis, and interpretation of data, and in writing the manuscript. Ethics approval and consent to participate: this study was conducted with the approval from the Ethics Committee of Guangdong TCM-lntegrated Hospital (2019-040). This study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants. Availability of data and materials: we declare that materials described in the manuscript, including all relevant raw data, will be freely available to any scientist wishing to use them for non-commercial purposes, without breaching participant confidentiality. were 19.2 % and 61.5 %, respectively, and the total effective rate was 80.7 %. In the control group, the CR rate and PR rate of local lesions were 10.5 % and 52.6 %, respectively, and the total effective rate was 63.1 %. The total effective rate was higher in the treatment group than in the control group, which was statistically significant (p < 0.05). Conclusion: the combination of a ([.sup.125]l) particle-integrated esophageal covered stent and hyperbaric oxygen shows a good short- and long-term efficacy in the treatment of advanced esophageal cancer. Keywords: ([.sup.125]l) radioactive seeds. Coate