Evaluation of efficiency omega 3 fatty acid improves the behavioural phenotype and protects against oxidative stress against [MPP.sup.+] induces Parkinson's disease in mice

This experiment proposed to study the efficiency omega 3 fatty acid on behavioural phenotype of Parkinson's disease (PD) in mice. Totally 7 groups (each group 6 mice) were used in this assessment, each groups were treated with saline (control), [MPP.sup.+], L-DOPA, Omega 3 oil, Omega 3 oil (three different concentrations) +[MPP.sup.+] separately. The behavioral assessments such as bar test, open field test, maze test, hang test were noted on 7th, 14th, 21st and 28th day. After the examination period, the tested animals' midbrains and frontal cortex were dissected to analyze TBARS, GSH, Catalase, Superoxide Dismutase and Glutathione Peroxidase assay. In the bar test, 500mg omega 3 fatty acid administrated mice showed a high cataleptic scores. In open field Test, significant reductions in behavior analysis were observed from the tested mice group. Maze test and hang test doesn't show much difference. In biochemical test, tested groups showed promising results compared to control group. The result strongly proved that the omega 3 fatty acid has remarkable abilities to control the neurodegenerative diseases. Keywords: Omega 3 oil, Parkinson's disease, Hang test, Maze test, open field test and catalepsy test.