CANNABIDIOL CONTENT EVALUATION IN COMMERCIAL DIETARY SUPPLEMENTS AND STABILITY IN OIL VEHICLE

Cannabidiol (CBD) is one of the most studied alkaloids found in Cannabis species. Also, its occurrence in Cannabis plants is higher in most of cases compared with the addictive compound named tetrahydrocannabinol (THC). This study aimed to evaluate CBD concentrations and stability in different commercial products and reconstituted oil. An UHPLC method previously published was applied. Three CBD oils and two powders marketed online together with a reconstituted oil were analyzed. The oils presented concentrations lower than stated on the label. The content of reconstituted CBD oils prepared similarly to the commercial oils decrease linearly with small differences based on the storage conditions. Thus, the CBD oil kept at temperatures of 5 [+ or -] 0.3[degrees]C tends to decompose slightly slower compared with the oil kept at room temperature. A stabilizer may be needed to slow the decomposition process. Future studies for reconstituted formulation may be needed to establish if the type of oil used is influencing the decomposition process. Keywords: CBD-oil, dietary supplements, storage, CBD powders, decomposition