Sperm CatSper ion channel swims into sharper focus

Sperm CatSper ion channel swims into sharper focus

Activation of the CatSper membrane ion channel triggers enhanced sperm motility, and this protein complex is required for male fertility. Structural data now provide insights into the channel, and offer a few surprises, too. Cryo-EM data sheds light on a protein complex needed for male fertility.

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Veröffentlicht in:Nature (London) 2021-07, Vol.595 (7869), p.654-655
Hauptverfasser: Clapham, David E., Hulse, Raymond E.
Format: Artikel
Sprache:eng
Schlagworte:
631/535
631/80
Humanities and Social Sciences
Ion channels
multidisciplinary
News And Views
Physiological aspects
Science
Spermatozoa
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Beschreibung
Zusammenfassung:Activation of the CatSper membrane ion channel triggers enhanced sperm motility, and this protein complex is required for male fertility. Structural data now provide insights into the channel, and offer a few surprises, too. Cryo-EM data sheds light on a protein complex needed for male fertility.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-021-01945-5