Estrogen-Like Substances from the Aerial Part of Ferula tschimganica

The optimal parameters influencing the extraction of the sum of terpenoid alcohol esters from the aerial part of Ferula tschimganica and purification of the obtained extract were found and made it possible to produce a final substance without green coloration. The technology for producing the sum of terpenoid alcohol esters from the aerial part of F. tschimganica was developed. Aspectrophotometric method for quantitative determination of the sum of terpenoid alcohol esters in chimphestrol substance (working name of the created agent) was proposed. Pharmacological studies found that terpenoid alcohol esters from the aerial part of F. tschimganica at a dose of 1 mg/kg exhibited a pronounced estrogenic effect in experiments on both immature and ovariectomized rats that was comparable to that of tefestrol and slightly inferior to that of the synthetic estrogenic drug Synestrol.