Antiviral drug Triazavirin, selectively labeled with .sup.2H, .sup.13C, and .sup.15N stable isotopes. Synthesis and properties
Isotope-labeled antiviral drug Triazavirin containing .sup.2H, .sup.13C, and .sup.15N atoms in its structure has been synthesized. .sup.13C.sup.2H.sub.3I and KS.sup.13CN served as donors of .sup.13C isotopes. The use of .sup.13С-MeI containing .sup.2H atoms made it possible to additionally incorpor...
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| Veröffentlicht in: | Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2021-04, Vol.57 (4), p.479 |
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| container_title | Chemistry of heterocyclic compounds (New York, N.Y. 1965) |
| container_volume | 57 |
| creator | Shestakova, Tatyana S Deev, Sergey L Khalymbadzha, Igor Ð Rusinov, Vladimir L Paramonov, Alexander S Arseniev, Alexander S Shenkarev, Zakhar O |
| description | Isotope-labeled antiviral drug Triazavirin containing .sup.2H, .sup.13C, and .sup.15N atoms in its structure has been synthesized. .sup.13C.sup.2H.sub.3I and KS.sup.13CN served as donors of .sup.13C isotopes. The use of .sup.13С-MeI containing .sup.2H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The .sup.15N atoms were incorporated using .sup.15N-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting .sup.2H.sub.3,.sup.13C.sub.2,.sup.15N.sub.3-Triazavirin was characterized by NMR spectroscopy. |
| doi_str_mv | 10.1007/s10593-021-02927-1 |
| format | Article |
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The resulting .sup.2H.sub.3,.sup.13C.sub.2,.sup.15N.sub.3-Triazavirin was characterized by NMR spectroscopy.</description><identifier>ISSN: 0009-3122</identifier><identifier>DOI: 10.1007/s10593-021-02927-1</identifier><language>eng</language><publisher>Springer</publisher><subject>Antiviral agents ; Labeling ; Nuclear magnetic resonance spectroscopy</subject><ispartof>Chemistry of heterocyclic compounds (New York, N.Y. 1965), 2021-04, Vol.57 (4), p.479</ispartof><rights>COPYRIGHT 2021 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Shestakova, Tatyana S</creatorcontrib><creatorcontrib>Deev, Sergey L</creatorcontrib><creatorcontrib>Khalymbadzha, Igor Ð</creatorcontrib><creatorcontrib>Rusinov, Vladimir L</creatorcontrib><creatorcontrib>Paramonov, Alexander S</creatorcontrib><creatorcontrib>Arseniev, Alexander S</creatorcontrib><creatorcontrib>Shenkarev, Zakhar O</creatorcontrib><title>Antiviral drug Triazavirin, selectively labeled with .sup.2H, .sup.13C, and .sup.15N stable isotopes. Synthesis and properties</title><title>Chemistry of heterocyclic compounds (New York, N.Y. 1965)</title><description>Isotope-labeled antiviral drug Triazavirin containing .sup.2H, .sup.13C, and .sup.15N atoms in its structure has been synthesized. .sup.13C.sup.2H.sub.3I and KS.sup.13CN served as donors of .sup.13C isotopes. The use of .sup.13С-MeI containing .sup.2H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The .sup.15N atoms were incorporated using .sup.15N-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting .sup.2H.sub.3,.sup.13C.sub.2,.sup.15N.sub.3-Triazavirin was characterized by NMR spectroscopy.</description><subject>Antiviral agents</subject><subject>Labeling</subject><subject>Nuclear magnetic resonance spectroscopy</subject><issn>0009-3122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptjD1PwzAQhj2ARCn8ASZLrE3wR2wnY1UBRapgoHvlj3Nr5CZVnILKwG_H0A4M6HS693nvvUPohpKSEqLuEiWi4QVhNHfDVEHP0IgQ0hScMnaBLlN6y6hoXY3Q17QdwnvodcSu36_xsg_6U2cjtBOcIILNa4gHHLXJ5PBHGDa4TPtdyeaTo6B8NsG6dScSzzgN2kTAIXVDt4NU4tdDO2wghfSb2_XZ7YcA6Qqdex0TXJ_mGC0f7pezebF4eXyaTRfFWqqqsDUzHKiwxhPDauWEc54xBr6RVjMlrBCsEcQbBqohUFkibCZnCJe1rPgY3R7frnWEVWh9N_TabkOyq6mUkjWEq59U-U8ql4NtsF0LPmT_z8E3JZpuSQ</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Shestakova, Tatyana S</creator><creator>Deev, Sergey L</creator><creator>Khalymbadzha, Igor Ð</creator><creator>Rusinov, Vladimir L</creator><creator>Paramonov, Alexander S</creator><creator>Arseniev, Alexander S</creator><creator>Shenkarev, Zakhar O</creator><general>Springer</general><scope/></search><sort><creationdate>20210401</creationdate><title>Antiviral drug Triazavirin, selectively labeled with .sup.2H, .sup.13C, and .sup.15N stable isotopes. 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| subjects | Antiviral agents Labeling Nuclear magnetic resonance spectroscopy |
| title | Antiviral drug Triazavirin, selectively labeled with .sup.2H, .sup.13C, and .sup.15N stable isotopes. Synthesis and properties |
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