Antiviral drug Triazavirin, selectively labeled with .sup.2H, .sup.13C, and .sup.15N stable isotopes. Synthesis and properties

Antiviral drug Triazavirin, selectively labeled with .sup.2H, .sup.13C, and .sup.15N stable isotopes. Synthesis and properties

Isotope-labeled antiviral drug Triazavirin containing .sup.2H, .sup.13C, and .sup.15N atoms in its structure has been synthesized. .sup.13C.sup.2H.sub.3I and KS.sup.13CN served as donors of .sup.13C isotopes. The use of .sup.13С-MeI containing .sup.2H atoms made it possible to additionally incorpor...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2021-04, Vol.57 (4), p.479
Hauptverfasser: Shestakova, Tatyana S, Deev, Sergey L, Khalymbadzha, Igor Ð, Rusinov, Vladimir L, Paramonov, Alexander S, Arseniev, Alexander S, Shenkarev, Zakhar O
Format: Artikel
Sprache:eng
Schlagworte:
Antiviral agents
Labeling
Nuclear magnetic resonance spectroscopy
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Zusammenfassung:Isotope-labeled antiviral drug Triazavirin containing .sup.2H, .sup.13C, and .sup.15N atoms in its structure has been synthesized. .sup.13C.sup.2H.sub.3I and KS.sup.13CN served as donors of .sup.13C isotopes. The use of .sup.13С-MeI containing .sup.2H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The .sup.15N atoms were incorporated using .sup.15N-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting .sup.2H.sub.3,.sup.13C.sub.2,.sup.15N.sub.3-Triazavirin was characterized by NMR spectroscopy.
ISSN:0009-3122
DOI:10.1007/s10593-021-02927-1