Clinical significance of serum transforming growth factor-[beta]1 and procollagen type I N-propeptide in post-tuberculosis tracheobronchial stenosis
Non-invasive strategies for monitoring post-tuberculosis (TB) tracheobronchial stenosis (PTTS) are clinically important but currently lacking. Transforming growth factor-[beta]1 (TGF-[beta]1) and procollagen type I N-propeptide (PINP) have been identified as markers of fibrosis. The present study ai...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2021-06, Vol.21 (6) |
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| creator | Wu, Yongchang Li, Yishi Bai, Yang Jiang, Jinyue Wang, Xiaohui Chen, Yi Wang, Xin Huang, Guichuan Gan, Yiling Li, You Guo, Shuliang |
| description | Non-invasive strategies for monitoring post-tuberculosis (TB) tracheobronchial stenosis (PTTS) are clinically important but currently lacking. Transforming growth factor-[beta]1 (TGF-[beta]1) and procollagen type I N-propeptide (PINP) have been identified as markers of fibrosis. The present study aimed to investigate the clinical significance of serum TGF-[beta]1 and PINP in PTTS. Serum samples were collected from 119 patients with tracheobronchial TB after the condition was treated for at least 6 months (59 patients with airway stenosis and 60 patients with no stenosis). Serum TGF-[beta]1 and PINP levels were measured using ELISA and compared between the groups. Relationships between serum TGF-[beta]1 and PINP levels and clinical characteristics, interventional bronchoscopy and outcomes of airway stenosis were analysed. The correlation between TGF-[beta]1 and PINP, and their diagnostic efficacy for airway stenosis were also analysed. The TGF-[beta]1 and PINP levels in the airway stenosis group were higher than those in the non-stenosis group. Furthermore, airway stenosis with atelectasis or mucus plugging was associated with higher TGF-[beta]1 levels, and airway stenosis with atelectasis, mucus plugging, right main bronchus stenosis or severe airway tracheal stenosis was associated with higher PINP levels. In addition, TGF-[beta]1 and PINP levels increased after interventional bronchoscopy therapy and airway stenosis with recurrent stenosis was associated with higher baseline levels of both markers. Finally, TGF-[beta]1 levels were positively correlated with PINP levels in patients with airway stenosis. The area under the receiver operating characteristic curve of TGF-[beta]1 and PINP for distinguishing airway stenosis from non-stenosis cases was 0.824 (95% CI: 0.748-0.900) and 0.863 (95% CI: 0.796-0.930), respectively. Therefore, TGF-[beta]1 and PINP are potential biomarkers that may be useful for diagnosing and monitoring PTTS. Key words: tracheobronchial tuberculosis, fibrosis, biomarker, transforming growth factor-[beta]1, procollagen type I N-propeptide |
| doi_str_mv | 10.3892/etm.2021.10002 |
| format | Article |
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Transforming growth factor-[beta]1 (TGF-[beta]1) and procollagen type I N-propeptide (PINP) have been identified as markers of fibrosis. The present study aimed to investigate the clinical significance of serum TGF-[beta]1 and PINP in PTTS. Serum samples were collected from 119 patients with tracheobronchial TB after the condition was treated for at least 6 months (59 patients with airway stenosis and 60 patients with no stenosis). Serum TGF-[beta]1 and PINP levels were measured using ELISA and compared between the groups. Relationships between serum TGF-[beta]1 and PINP levels and clinical characteristics, interventional bronchoscopy and outcomes of airway stenosis were analysed. The correlation between TGF-[beta]1 and PINP, and their diagnostic efficacy for airway stenosis were also analysed. The TGF-[beta]1 and PINP levels in the airway stenosis group were higher than those in the non-stenosis group. Furthermore, airway stenosis with atelectasis or mucus plugging was associated with higher TGF-[beta]1 levels, and airway stenosis with atelectasis, mucus plugging, right main bronchus stenosis or severe airway tracheal stenosis was associated with higher PINP levels. In addition, TGF-[beta]1 and PINP levels increased after interventional bronchoscopy therapy and airway stenosis with recurrent stenosis was associated with higher baseline levels of both markers. Finally, TGF-[beta]1 levels were positively correlated with PINP levels in patients with airway stenosis. The area under the receiver operating characteristic curve of TGF-[beta]1 and PINP for distinguishing airway stenosis from non-stenosis cases was 0.824 (95% CI: 0.748-0.900) and 0.863 (95% CI: 0.796-0.930), respectively. Therefore, TGF-[beta]1 and PINP are potential biomarkers that may be useful for diagnosing and monitoring PTTS. Key words: tracheobronchial tuberculosis, fibrosis, biomarker, transforming growth factor-[beta]1, procollagen type I N-propeptide</description><identifier>ISSN: 1792-0981</identifier><identifier>DOI: 10.3892/etm.2021.10002</identifier><language>eng</language><publisher>Spandidos Publications</publisher><subject>Biological markers ; Care and treatment ; Cellular proteins ; Complications and side effects ; Development and progression ; Genetic aspects ; Health aspects ; Identification and classification ; Stenosis ; Transforming growth factors ; Tuberculosis</subject><ispartof>Experimental and therapeutic medicine, 2021-06, Vol.21 (6)</ispartof><rights>COPYRIGHT 2021 Spandidos Publications</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Wu, Yongchang</creatorcontrib><creatorcontrib>Li, Yishi</creatorcontrib><creatorcontrib>Bai, Yang</creatorcontrib><creatorcontrib>Jiang, Jinyue</creatorcontrib><creatorcontrib>Wang, Xiaohui</creatorcontrib><creatorcontrib>Chen, Yi</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Huang, Guichuan</creatorcontrib><creatorcontrib>Gan, Yiling</creatorcontrib><creatorcontrib>Li, You</creatorcontrib><creatorcontrib>Guo, Shuliang</creatorcontrib><title>Clinical significance of serum transforming growth factor-[beta]1 and procollagen type I N-propeptide in post-tuberculosis tracheobronchial stenosis</title><title>Experimental and therapeutic medicine</title><description>Non-invasive strategies for monitoring post-tuberculosis (TB) tracheobronchial stenosis (PTTS) are clinically important but currently lacking. Transforming growth factor-[beta]1 (TGF-[beta]1) and procollagen type I N-propeptide (PINP) have been identified as markers of fibrosis. The present study aimed to investigate the clinical significance of serum TGF-[beta]1 and PINP in PTTS. Serum samples were collected from 119 patients with tracheobronchial TB after the condition was treated for at least 6 months (59 patients with airway stenosis and 60 patients with no stenosis). Serum TGF-[beta]1 and PINP levels were measured using ELISA and compared between the groups. Relationships between serum TGF-[beta]1 and PINP levels and clinical characteristics, interventional bronchoscopy and outcomes of airway stenosis were analysed. The correlation between TGF-[beta]1 and PINP, and their diagnostic efficacy for airway stenosis were also analysed. The TGF-[beta]1 and PINP levels in the airway stenosis group were higher than those in the non-stenosis group. Furthermore, airway stenosis with atelectasis or mucus plugging was associated with higher TGF-[beta]1 levels, and airway stenosis with atelectasis, mucus plugging, right main bronchus stenosis or severe airway tracheal stenosis was associated with higher PINP levels. In addition, TGF-[beta]1 and PINP levels increased after interventional bronchoscopy therapy and airway stenosis with recurrent stenosis was associated with higher baseline levels of both markers. Finally, TGF-[beta]1 levels were positively correlated with PINP levels in patients with airway stenosis. The area under the receiver operating characteristic curve of TGF-[beta]1 and PINP for distinguishing airway stenosis from non-stenosis cases was 0.824 (95% CI: 0.748-0.900) and 0.863 (95% CI: 0.796-0.930), respectively. Therefore, TGF-[beta]1 and PINP are potential biomarkers that may be useful for diagnosing and monitoring PTTS. Key words: tracheobronchial tuberculosis, fibrosis, biomarker, transforming growth factor-[beta]1, procollagen type I N-propeptide</description><subject>Biological markers</subject><subject>Care and treatment</subject><subject>Cellular proteins</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Identification and classification</subject><subject>Stenosis</subject><subject>Transforming growth factors</subject><subject>Tuberculosis</subject><issn>1792-0981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptjjtPwzAUhT2ARFW6MltiTvEjie2xqnhUqmCADaHKca5To8SObFeI_8EPJhEMDOgO9-o75x4dhK4oWXOp2A3kYc0Io2tKCGFnaEGFYgVRkl6gVUrvEyVVTaWsFuhr2zvvjO5xcp13djq9ARwsThBPA85R-2RDHJzvcBfDRz5iq00OsXhtIOs3irVv8RiDCX2vO_A4f46Ad_ixmOAIY3YtYOfxGFIu8qmBaE59SC7N2eYIoYnBm6ObK2Tws3KJzq3uE6x-9xI9392-bB-K_dP9brvZF10teGFtrUSptTCcl7LSTDLZUAEtpUZURFhVNq0gTBGlwBpZAtCGMU0ka7gQfImuf1I73cPBeRvmQoNL5rCpayZ5TRSfXOt_XNO0MDgTPFg38T8P30WEeQc</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Wu, Yongchang</creator><creator>Li, Yishi</creator><creator>Bai, Yang</creator><creator>Jiang, Jinyue</creator><creator>Wang, Xiaohui</creator><creator>Chen, Yi</creator><creator>Wang, Xin</creator><creator>Huang, Guichuan</creator><creator>Gan, Yiling</creator><creator>Li, You</creator><creator>Guo, Shuliang</creator><general>Spandidos Publications</general><scope/></search><sort><creationdate>20210601</creationdate><title>Clinical significance of serum transforming growth factor-[beta]1 and procollagen type I N-propeptide in post-tuberculosis tracheobronchial stenosis</title><author>Wu, Yongchang ; Li, Yishi ; Bai, Yang ; Jiang, Jinyue ; Wang, Xiaohui ; Chen, Yi ; Wang, Xin ; Huang, Guichuan ; Gan, Yiling ; Li, You ; Guo, Shuliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g673-ff6974aa7c33485a2828b17ed11c7507f94bd7029099efc84ee1b22a082b3773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biological markers</topic><topic>Care and treatment</topic><topic>Cellular proteins</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Identification and classification</topic><topic>Stenosis</topic><topic>Transforming growth factors</topic><topic>Tuberculosis</topic><toplevel>online_resources</toplevel><creatorcontrib>Wu, Yongchang</creatorcontrib><creatorcontrib>Li, Yishi</creatorcontrib><creatorcontrib>Bai, Yang</creatorcontrib><creatorcontrib>Jiang, Jinyue</creatorcontrib><creatorcontrib>Wang, Xiaohui</creatorcontrib><creatorcontrib>Chen, Yi</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Huang, Guichuan</creatorcontrib><creatorcontrib>Gan, Yiling</creatorcontrib><creatorcontrib>Li, You</creatorcontrib><creatorcontrib>Guo, Shuliang</creatorcontrib><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Yongchang</au><au>Li, Yishi</au><au>Bai, Yang</au><au>Jiang, Jinyue</au><au>Wang, Xiaohui</au><au>Chen, Yi</au><au>Wang, Xin</au><au>Huang, Guichuan</au><au>Gan, Yiling</au><au>Li, You</au><au>Guo, Shuliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of serum transforming growth factor-[beta]1 and procollagen type I N-propeptide in post-tuberculosis tracheobronchial stenosis</atitle><jtitle>Experimental and therapeutic medicine</jtitle><date>2021-06-01</date><risdate>2021</risdate><volume>21</volume><issue>6</issue><issn>1792-0981</issn><abstract>Non-invasive strategies for monitoring post-tuberculosis (TB) tracheobronchial stenosis (PTTS) are clinically important but currently lacking. Transforming growth factor-[beta]1 (TGF-[beta]1) and procollagen type I N-propeptide (PINP) have been identified as markers of fibrosis. The present study aimed to investigate the clinical significance of serum TGF-[beta]1 and PINP in PTTS. Serum samples were collected from 119 patients with tracheobronchial TB after the condition was treated for at least 6 months (59 patients with airway stenosis and 60 patients with no stenosis). Serum TGF-[beta]1 and PINP levels were measured using ELISA and compared between the groups. Relationships between serum TGF-[beta]1 and PINP levels and clinical characteristics, interventional bronchoscopy and outcomes of airway stenosis were analysed. The correlation between TGF-[beta]1 and PINP, and their diagnostic efficacy for airway stenosis were also analysed. The TGF-[beta]1 and PINP levels in the airway stenosis group were higher than those in the non-stenosis group. Furthermore, airway stenosis with atelectasis or mucus plugging was associated with higher TGF-[beta]1 levels, and airway stenosis with atelectasis, mucus plugging, right main bronchus stenosis or severe airway tracheal stenosis was associated with higher PINP levels. In addition, TGF-[beta]1 and PINP levels increased after interventional bronchoscopy therapy and airway stenosis with recurrent stenosis was associated with higher baseline levels of both markers. Finally, TGF-[beta]1 levels were positively correlated with PINP levels in patients with airway stenosis. The area under the receiver operating characteristic curve of TGF-[beta]1 and PINP for distinguishing airway stenosis from non-stenosis cases was 0.824 (95% CI: 0.748-0.900) and 0.863 (95% CI: 0.796-0.930), respectively. Therefore, TGF-[beta]1 and PINP are potential biomarkers that may be useful for diagnosing and monitoring PTTS. Key words: tracheobronchial tuberculosis, fibrosis, biomarker, transforming growth factor-[beta]1, procollagen type I N-propeptide</abstract><pub>Spandidos Publications</pub><doi>10.3892/etm.2021.10002</doi></addata></record> |
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| subjects | Biological markers Care and treatment Cellular proteins Complications and side effects Development and progression Genetic aspects Health aspects Identification and classification Stenosis Transforming growth factors Tuberculosis |
| title | Clinical significance of serum transforming growth factor-[beta]1 and procollagen type I N-propeptide in post-tuberculosis tracheobronchial stenosis |
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