Clinical significance of serum transforming growth factor-[beta]1 and procollagen type I N-propeptide in post-tuberculosis tracheobronchial stenosis
Non-invasive strategies for monitoring post-tuberculosis (TB) tracheobronchial stenosis (PTTS) are clinically important but currently lacking. Transforming growth factor-[beta]1 (TGF-[beta]1) and procollagen type I N-propeptide (PINP) have been identified as markers of fibrosis. The present study ai...
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Veröffentlicht in: | Experimental and therapeutic medicine 2021-06, Vol.21 (6) |
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Zusammenfassung: | Non-invasive strategies for monitoring post-tuberculosis (TB) tracheobronchial stenosis (PTTS) are clinically important but currently lacking. Transforming growth factor-[beta]1 (TGF-[beta]1) and procollagen type I N-propeptide (PINP) have been identified as markers of fibrosis. The present study aimed to investigate the clinical significance of serum TGF-[beta]1 and PINP in PTTS. Serum samples were collected from 119 patients with tracheobronchial TB after the condition was treated for at least 6 months (59 patients with airway stenosis and 60 patients with no stenosis). Serum TGF-[beta]1 and PINP levels were measured using ELISA and compared between the groups. Relationships between serum TGF-[beta]1 and PINP levels and clinical characteristics, interventional bronchoscopy and outcomes of airway stenosis were analysed. The correlation between TGF-[beta]1 and PINP, and their diagnostic efficacy for airway stenosis were also analysed. The TGF-[beta]1 and PINP levels in the airway stenosis group were higher than those in the non-stenosis group. Furthermore, airway stenosis with atelectasis or mucus plugging was associated with higher TGF-[beta]1 levels, and airway stenosis with atelectasis, mucus plugging, right main bronchus stenosis or severe airway tracheal stenosis was associated with higher PINP levels. In addition, TGF-[beta]1 and PINP levels increased after interventional bronchoscopy therapy and airway stenosis with recurrent stenosis was associated with higher baseline levels of both markers. Finally, TGF-[beta]1 levels were positively correlated with PINP levels in patients with airway stenosis. The area under the receiver operating characteristic curve of TGF-[beta]1 and PINP for distinguishing airway stenosis from non-stenosis cases was 0.824 (95% CI: 0.748-0.900) and 0.863 (95% CI: 0.796-0.930), respectively. Therefore, TGF-[beta]1 and PINP are potential biomarkers that may be useful for diagnosing and monitoring PTTS. Key words: tracheobronchial tuberculosis, fibrosis, biomarker, transforming growth factor-[beta]1, procollagen type I N-propeptide |
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ISSN: | 1792-0981 |
DOI: | 10.3892/etm.2021.10002 |