KILLER IMMUNOGLOBULINE LIKE RECEPTOR GENE ANALYSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION WITH AUTOIMMUNITY/KRONIK LENFOSITIK LOSEMI TANILI HASTALARDA KILLER IMMUNOGLOBULIN LIKE RESEPTOR GEN DUZEYLERI VE OTOIMMUN OLAYLAR ILE ILISKISI

Objective: Our study was performed on 49 chronic lymphocytic leukemia (CLL) patients followed in the outpatient clinic of the Istanbul University Cerrahpasa Medical Faculty Department of Hematology. We aimed to analyze the relationship between autoimmune phenomena and CLL. Methods: Twenty-five CLL patients with and 24 CLL patients without autoimmune phenomenon were included. Thirty-two of them were male and 17 were female. No statistically significant difference in the median age at diagnosis (60 vs 64) and in the median follow-up time (59 months vs 71 months) was detected. The initial diagnostic parameters were similar. Results: In our autoimmune phenomenon cohort, the most frequent autoimmune disease was autoimmune hemolytic anemia (AIHA) followed by immune thrombocytopenia (ITP) and pure red cell aplasia (PRCA). The direct antiglobulin positivity at the time of diagnosis was increased in the autoimmune phenomenon group (p=0.024). Additionally, the stage of CLL in patients of the autoimmune phenomenon group was more advanced than the other group (p=0.04). Although the number of autoimmune phenomena was not high enough, the CD38 positive cell ratio over 30% in the peripheral blood was more frequent in PRCA group (p=0.008). Conclusion: We could not determine a relationship between autoimmunity in CLL and KIR genotypes. We believe that a new study in a larger cohort with superior technical conditions should be planned to find accurate responses to our study. Keywords: Chronic lymphocytic leukemia, Killer immunoglobuline like receptor, autoimmunity, autoimmune hemolytic anemia, immune thrombocytopenic purpura, pure erythroid aplasia Amac: Istanbul Universitesi Cerrahpasa Tip Fakultesi Hematoloji Poliklinigi'nde takip edilen 49 Kronik Lenfositik Losemi (KLL) hastasi calismaya dahil edilmistir. Calismanin amaci, cesitli otoimmun hastaliklar ile iliskisi gosterilmis olan Killer Immunoglobuline Like Receptor (KIR) gen duzeylerini, otoimmun olay gozlenmis ve gozlenmemis KLL hasta gruplari arasinda karsilastirmaktir. Gerec ve Yontem: Bu dogrultuda otoimmun olay gozlenmis olan 25 ve otoimmun olay gozlenmemis 24 KLL hastasi calismaya dahil edilmistir. Hastalarin 32'si erkek, 17'si kadindir. Otoimmun hastalik gozlenen grup ile otoimmun olay gozlenmeyen KLL grubu arasinda tani anindaki yas (60 vs 64) ve ortanca takip suresi (59 ay vs 71 ay), tani anindaki parametreleri istatistiki olarak benzerdir. Bulgular: Gozlenen en sik otoimmun olay otoimmun hemolitik anemi (OIHA