The m.sup.1A landscape on cytosolic and mitochondrial mRNA at single-base resolution

The m.sup.1A landscape on cytosolic and mitochondrial mRNA at single-base resolution

Transcriptome-wide mapping of N1-methyladenosine (m.sup.1A) at single-nucleotide resolution reveals m.sup.1A to be scarce in cytoplasmic mRNA, to inhibit translation, and to be highly dynamic at a single site in a mitochondrial mRNA.

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Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 2017-11, Vol.551 (7680), p.251
Hauptverfasser: Safra, Modi, Sas-Chen, Aldema, Nir, Ronit, Winkler, Roni, Nachshon, Aharon, Bar-Yaacov, Dan, Erlacher, Matthias
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Genetic aspects
Genetic translation
Messenger RNA
Methods
Methylation
Transfer RNA
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Zusammenfassung:Transcriptome-wide mapping of N1-methyladenosine (m.sup.1A) at single-nucleotide resolution reveals m.sup.1A to be scarce in cytoplasmic mRNA, to inhibit translation, and to be highly dynamic at a single site in a mitochondrial mRNA.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature24456