Cervical dysplasia after renal transplantation: A retrospective cohort study/Renal transplantasyon sonrasi servikal displazi: Retrospektif bir kohort calismasi

Objective: Since the first days of organ transplantation, it has been accepted that solid transplant recipients have a high risk of developing cancer. Chronic immunosuppression and environmental factors play a role in cancer development in recipients. In the present study, we tried to evaluate the cumulative incidence of cervical dysplasia after renal transplantation, risk factors for disease development, and the time until high-grade dysplasia occurred. Materials and Methods: A total of 50 patients with renal transplantation who presented for gynecologic follow-up was included in the study. The medical records of the patients were reviewed until the last clinical visit, their demographic characteristics, transplant history, gynecologic history, and gynecologic examination results (cervical cytology and histology reports) were reviewed. Results: Of the 50 women in the study population, 29 (58%; 95% confidence interval: 8.8-15.9) developed cervical dysplasia after the first transplant at a median follow-up of 7.8 (range: 4.6-12.9) years. Twenty-one women with benign cervical cytology before transplantation had evidence of low-grade intraepithelial lesions + after transplant (47% of these were within 2 years after transplant). During the follow-up, 8 women (18.2%) were diagnosed as having high-grade intraepithelial lesions + (within 5 years after transplantation). Conclusion: Renal transplant patients were found to have higher abnormal cervical cytology and histology rates than the normal population. Keywords: Immunosuppression, cervical dysplasia, renal transplantation Amac: Organ naklinin ilk gunlerinden bu yana, nakil alicilarinin kansere yakalanma riskinin yuksek oldugu kabul edilmisUr. Kronik immunosupresyon ve cevresel faktorler, alicilarda kanser gelisiminde rol oynar. Sunulan calismada, renal transplantasyon sonrasi kumulatif servikal displazi insidansini, hastalik gelisimi icin risk faktorlerini ve yuksek dereceli displazinin ortaya cikmasina kadar gecen sureyi degerlendirmeye calistik. Gerec ve Yontemler: Calismaya jinekolojik takip icin basvuran toplam 50 renal transplantasyon hastasi dahil edildi. Hastalarin tibbi kayitlari son klinik ziyarete kadar gozden gecirildi, demografik ozellikleri, nakil oykuleri, jinekolojik oykuleri ve jinekolojik muayene sonuclari (servikal sitoloji ve histoloji raporlari) gozden gecirildi. Bulgular: Calisma populasyonundaki 50 kadindan 29'u (%58; %95 guven araligi: 8,8-15,9) ortalama 7,8 yillik bir takip suresinde (4