Combination of aqueous extracts of Curcuma longa and some calcium channel blockers synergistically improves C[Cl.sub.4]-induced nephrotoxicity in albino rats

In the present study, special attention was drawn to C[Cl.sub.4]-induced acute kidney injury (AKI) and how the nephrotoxicity could be treated or prevented by administration of aqueous extracts of Curcuma longa (AECL) alone or in combination with some calcium channel blockers. Thirty (30) male albino wister rats were grouped according to their weight into 6 groups (A-F) of 5 rats per group. Rats in groups A-D received C[Cl.sub.4] (0.4ml/kg b.wt, i.p) for 3 days. Group B received AECL (200mg/kg, oral), Group C received AECL and nifedipine (1mg/100g of rat, i.p), Group D received AECL and amlodipine (1mg/100g of rat, i.p), and group E received AECL alone with no C[Cl.sub.4] challenge for 3 days. No treatment was administered to group F (Normal control). Serum renal biochemical parameters; MDA level and SOD activity in the kidney homogenates were measured. C[Cl.sub.4] administration to the rats resulted to acute kidney injury with significantly increased Urea, Creatinine, [K.sup.+] and MDA levels and decreased SOD activity (p