Pd(PPh3)(4) Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug

A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches. The as-prepared indazole derivatives (3a-3j) and their N-methyl derivatives (5a-5j) are evaluated for in...

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Veröffentlicht in:	Applied sciences 2020-06, Vol.10 (11), Article 3792
Hauptverfasser:	Saketi, Jagan Mohana Rao, Boddapati, S. N. Murthy, Raghuram, M., Adil, Syed Farooq, Shaik, Mohammed Rafi, Alduhaish, Osamah, Siddiqui, Mohammed Rafiq H., Bollikolla, Hari Babu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic agents Antineoplastic agents Cancer cells Chemistry Chemistry, Multidisciplinary Comparative analysis Engineering Engineering, Multidisciplinary Evaluation Heterocyclic aromatic compounds Identification and classification Materials Science Materials Science, Multidisciplinary Palladium catalysts Pharmaceutical industry Physical Sciences Physics Physics, Applied Product development Production processes Science & Technology Technology Testing
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Beschreibung
Zusammenfassung:	A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches. The as-prepared indazole derivatives (3a-3j) and their N-methyl derivatives (5a-5j) are evaluated for in vitro anticancer activity against two cancer cell lines, HCT-116 and MDA-MB-231. The results reveal that the indazole derivatives tested display mild to moderate anticancer activities against the cell lines tested.
ISSN:	2076-3417 2076-3417
DOI:	10.3390/app10113792