Synthesis of Nʹ-Nicotinoyl Sulfonohydrazides and their Antimicrobial Activity

Nʹ-Nicotinoyl sulfonohydrazide derivatives 3-13 were synthesized from nicotinyl hydrazide and evaluated for their antimicrobial potential against Gram positive bacterial strains (Bacillus cereus, Bacillus subtilis, Corynebacterium diphtheriae, Staphylococcus fecalis, Staphylococcus aureus, and MRSA (Methicillin-resistant Staphylococcus aureus)) and Gram negative bacterial strains (Escherichia.coli, Pseudomonas aeruginosa, Salmonella ParatyphiB, Salmonella tyhpi). Compound 13 showed outstanding antibacterial activity against Staphylococcus fecalis and compounds 7 and 13 were found to be moderately activite against Salmonella Paratyphi B, shown by their zone of inhibition values. In addition to that compond 9 also showed moderate activity against Escherichia coli. All derivatives 3-13 were also subjected for the evaluation of their antifungal activity against Saccharomyces cerevisiae, Microsporum canin, Rhizopus, Aspergillus niger, Candida albicans, and Candida tropicalis. Compound 13 showed promising antifungal activity against Rhizopus sp. and compounds 9 and 10 showed moderate antifungal potential against Microsporum canis, Aspergillus niger, and Candida tropicalis. Other molecules demonstrated weak zone of inhibitions.