Application of Focal Photoinduced Thrombosis for Modeling Spinal Cord Ischemia

Typical ischemic damage to neurons were detected in the focus of experimental photothrombosis and in the transition zone. They were associated with symptoms of impaired motor functions and dysfunction of pelvic organs. The applied method of focal photothrombosis can be used for simulation of spinal...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2020-02, Vol.168 (4), p.525-528
Hauptverfasser:	Pashin, S. S., Kuznetsov, S. L., Pashina, N. R., Tsomartova, D. A., Chereshneva, E. V., Ivanova, M. Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Blood clot Cell Biology Disease Models, Animal Internal Medicine Ischemia Laboratory Medicine Male Motor Activity - radiation effects Neurons Neurons - pathology Neurons - radiation effects Neurons - ultrastructure Pathology Rats Rats, Wistar Resveratrol Spinal Cord - pathology Spinal Cord - radiation effects Spinal Cord Ischemia - etiology Spinal Cord Ischemia - pathology Thrombosis Thrombosis - etiology Thrombosis - pathology Ultraviolet Rays - adverse effects
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Zusammenfassung:	Typical ischemic damage to neurons were detected in the focus of experimental photothrombosis and in the transition zone. They were associated with symptoms of impaired motor functions and dysfunction of pelvic organs. The applied method of focal photothrombosis can be used for simulation of spinal cord ischemia for the development of methods for pharmacological correction and restoration of impaired sensorimotor functions.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-020-04746-4