Preexisting influenza-specific CD4.sup.+ T cells correlate with disease protection against influenza challenge in humans

Preexisting influenza-specific CD4.sup.+ T cells correlate with disease protection against influenza challenge in humans

The role of T cells in modulating the course of influenza infection in humans is not clear. Wilkinson et al. now report that, in the absence of strain-specific humoral immunity, preexisting cytotoxic CD4.sup.+ T cells limit the severity and duration of symptoms in humans challenged with influenza vi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature medicine 2012-02, Vol.18 (2), p.274
Hauptverfasser: Wilkinson, Tom M, Li, Chris K F, Chui, Cecilia S C, Huang, Arthur K Y, Perkins, Molly, Liebner, Julia C, Lambkin-Williams, Rob
Format: Artikel
Sprache:eng
Schlagworte:
AIDS vaccines
Antibodies
CD4 lymphocytes
Development and progression
Diseases
Infection
Influenza
Influenza vaccines
Influenza viruses
Medical research
Peptides
Physiological aspects
Prevention
Proteins
T cells
Vaccines
Virus diseases
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The role of T cells in modulating the course of influenza infection in humans is not clear. Wilkinson et al. now report that, in the absence of strain-specific humoral immunity, preexisting cytotoxic CD4.sup.+ T cells limit the severity and duration of symptoms in humans challenged with influenza virus and suggest these CD4.sup.+ T cell responses might be harnessed in vaccine development.
ISSN:1078-8956
1546-170X
DOI:10.1038/nm.2612