A Study on the Presence of Osteopontin and [alpha]3[beta]1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation
Background: Embryo implantation is a critical and multifactorial phenomenon which can be affected by any alteration in molecular micro construction of endometrium. The aim of the current study was to evaluate the effects of diabetes on osteopontin (OPN) and [alpha]3[beta]1 integrin proteins level at...
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| Veröffentlicht in: | Faṣlnāmah-i pizishkī-i bārvar va nābārvar 2020-04, Vol.21 (2), p.87 |
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| container_title | Faṣlnāmah-i pizishkī-i bārvar va nābārvar |
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| creator | Zarrin, Yasaman Bakhteyari, Abbas Nikpour, Parvaneh Mostafavi, Fatemeh Sadat Eskandari, Nahid Matinfar, Mohammad Aboutorabi, Roshanak |
| description | Background: Embryo implantation is a critical and multifactorial phenomenon which can be affected by any alteration in molecular micro construction of endometrium. The aim of the current study was to evaluate the effects of diabetes on osteopontin (OPN) and [alpha]3[beta]1 integrin proteins level at the time of endometrial receptivity. Methods: Twenty-eight female rats were divided into control, diabetic, pioglitazonetreated and metformin-treated groups. Western blot was performed to determine the OPN and [alpha]3[beta]1 integrin proteins in rats' endometrium at the time of implantation. Data were analyzed by analysis of variance (ANOVA) and p |
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The aim of the current study was to evaluate the effects of diabetes on osteopontin (OPN) and [alpha]3[beta]1 integrin proteins level at the time of endometrial receptivity. Methods: Twenty-eight female rats were divided into control, diabetic, pioglitazonetreated and metformin-treated groups. Western blot was performed to determine the OPN and [alpha]3[beta]1 integrin proteins in rats' endometrium at the time of implantation. Data were analyzed by analysis of variance (ANOVA) and p<0.05 was considered statistically significant. Results: OPN increased significantly in the diabetic group in comparison with control (p<0.001), metformin-treated (p=0.008) and pioglitazone-treated groups (p< 0.001). Furthermore, [alpha]3[beta]1 integrin protein level in diabetic group had a significant difference in comparison with that of the control (p<0.001), metformin-treated (p= 0.026) and pioglitazone-treated groups (p<0.001). Conclusion: OPN and [alpha]3[beta]1 integrin proteins are involved in embryo implantation and their changes in diabetic condition can affect fertility. Treatment with pioglitazone and metformin improved the level of OPN and [alpha]3[beta]1 integrin proteins while pioglitazone was more effective. Keywords: Diabetes mellitus, Endometrium, Osteopontin, [alpha]3[beta]1 integrin. To cite this article: Zarrin Y, Bakhteyari A, Nikpour P, Mostafavi FS, Eskandari N, Matinfar M, et al. A Study on the Presence of Osteopontin and [alpha]3[beta]1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation. J Reprod Infertil. 2020;21(2):87-93.</description><identifier>ISSN: 1726-7536</identifier><language>eng</language><publisher>Avicenna Research Institute</publisher><subject>Diabetes mellitus ; Diabetes therapy ; Embryo ; Embryonic development ; Integrins ; Proteins ; Type 2 diabetes</subject><ispartof>Faṣlnāmah-i pizishkī-i bārvar va nābārvar, 2020-04, Vol.21 (2), p.87</ispartof><rights>COPYRIGHT 2020 Avicenna Research Institute</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Zarrin, Yasaman</creatorcontrib><creatorcontrib>Bakhteyari, Abbas</creatorcontrib><creatorcontrib>Nikpour, Parvaneh</creatorcontrib><creatorcontrib>Mostafavi, Fatemeh Sadat</creatorcontrib><creatorcontrib>Eskandari, Nahid</creatorcontrib><creatorcontrib>Matinfar, Mohammad</creatorcontrib><creatorcontrib>Aboutorabi, Roshanak</creatorcontrib><title>A Study on the Presence of Osteopontin and [alpha]3[beta]1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation</title><title>Faṣlnāmah-i pizishkī-i bārvar va nābārvar</title><description>Background: Embryo implantation is a critical and multifactorial phenomenon which can be affected by any alteration in molecular micro construction of endometrium. The aim of the current study was to evaluate the effects of diabetes on osteopontin (OPN) and [alpha]3[beta]1 integrin proteins level at the time of endometrial receptivity. Methods: Twenty-eight female rats were divided into control, diabetic, pioglitazonetreated and metformin-treated groups. Western blot was performed to determine the OPN and [alpha]3[beta]1 integrin proteins in rats' endometrium at the time of implantation. Data were analyzed by analysis of variance (ANOVA) and p<0.05 was considered statistically significant. Results: OPN increased significantly in the diabetic group in comparison with control (p<0.001), metformin-treated (p=0.008) and pioglitazone-treated groups (p< 0.001). Furthermore, [alpha]3[beta]1 integrin protein level in diabetic group had a significant difference in comparison with that of the control (p<0.001), metformin-treated (p= 0.026) and pioglitazone-treated groups (p<0.001). Conclusion: OPN and [alpha]3[beta]1 integrin proteins are involved in embryo implantation and their changes in diabetic condition can affect fertility. Treatment with pioglitazone and metformin improved the level of OPN and [alpha]3[beta]1 integrin proteins while pioglitazone was more effective. Keywords: Diabetes mellitus, Endometrium, Osteopontin, [alpha]3[beta]1 integrin. To cite this article: Zarrin Y, Bakhteyari A, Nikpour P, Mostafavi FS, Eskandari N, Matinfar M, et al. A Study on the Presence of Osteopontin and [alpha]3[beta]1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation. J Reprod Infertil. 2020;21(2):87-93.</description><subject>Diabetes mellitus</subject><subject>Diabetes therapy</subject><subject>Embryo</subject><subject>Embryonic development</subject><subject>Integrins</subject><subject>Proteins</subject><subject>Type 2 diabetes</subject><issn>1726-7536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptj8FqAjEQhvfQQsX6DoFCb1vcZJNNjmJtKwiW1puITLKzbspuIpt48BX61F21BwudOQzMfN8Pc5MMsoKKtOBM3CWjEL7GfTElGKeD5HtCPuOhPBLvSKyRvHcY0BkkviLLENHvvYvWEXAlWUOzr2HD1hojbDIydxF3XX-0F3fmSt9i7OyhPenPFnrQGvIBMRCIZ2Zl23P2rNXd0ZN5u2_ARYjWu_vktoIm4Oh3DpPVy2w1fUsXy9f5dLJId0rStNTMUKg0MmZAZ1LpLCuUzJBLjUrguBhXyI3IheJKYg7SyIJTLoWilFclGyYPl9gdNLi1rvKxA9PaYLYTQVmhcqVoTz39Q_VdYmuNd1jZfv9HeLwSaoQm1sE3h9Nn4Rr8AR57euQ</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Zarrin, Yasaman</creator><creator>Bakhteyari, Abbas</creator><creator>Nikpour, Parvaneh</creator><creator>Mostafavi, Fatemeh Sadat</creator><creator>Eskandari, Nahid</creator><creator>Matinfar, Mohammad</creator><creator>Aboutorabi, Roshanak</creator><general>Avicenna Research Institute</general><scope/></search><sort><creationdate>20200401</creationdate><title>A Study on the Presence of Osteopontin and [alpha]3[beta]1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation</title><author>Zarrin, Yasaman ; Bakhteyari, Abbas ; Nikpour, Parvaneh ; Mostafavi, Fatemeh Sadat ; Eskandari, Nahid ; Matinfar, Mohammad ; Aboutorabi, Roshanak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g982-db3c2afbe33cab189b117981e58be96e070fe5c6469598e4a8c87525869225fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Diabetes mellitus</topic><topic>Diabetes therapy</topic><topic>Embryo</topic><topic>Embryonic development</topic><topic>Integrins</topic><topic>Proteins</topic><topic>Type 2 diabetes</topic><toplevel>online_resources</toplevel><creatorcontrib>Zarrin, Yasaman</creatorcontrib><creatorcontrib>Bakhteyari, Abbas</creatorcontrib><creatorcontrib>Nikpour, Parvaneh</creatorcontrib><creatorcontrib>Mostafavi, Fatemeh Sadat</creatorcontrib><creatorcontrib>Eskandari, Nahid</creatorcontrib><creatorcontrib>Matinfar, Mohammad</creatorcontrib><creatorcontrib>Aboutorabi, Roshanak</creatorcontrib><jtitle>Faṣlnāmah-i pizishkī-i bārvar va nābārvar</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zarrin, Yasaman</au><au>Bakhteyari, Abbas</au><au>Nikpour, Parvaneh</au><au>Mostafavi, Fatemeh Sadat</au><au>Eskandari, Nahid</au><au>Matinfar, Mohammad</au><au>Aboutorabi, Roshanak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Study on the Presence of Osteopontin and [alpha]3[beta]1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation</atitle><jtitle>Faṣlnāmah-i pizishkī-i bārvar va nābārvar</jtitle><date>2020-04-01</date><risdate>2020</risdate><volume>21</volume><issue>2</issue><spage>87</spage><pages>87-</pages><issn>1726-7536</issn><abstract>Background: Embryo implantation is a critical and multifactorial phenomenon which can be affected by any alteration in molecular micro construction of endometrium. The aim of the current study was to evaluate the effects of diabetes on osteopontin (OPN) and [alpha]3[beta]1 integrin proteins level at the time of endometrial receptivity. Methods: Twenty-eight female rats were divided into control, diabetic, pioglitazonetreated and metformin-treated groups. Western blot was performed to determine the OPN and [alpha]3[beta]1 integrin proteins in rats' endometrium at the time of implantation. Data were analyzed by analysis of variance (ANOVA) and p<0.05 was considered statistically significant. Results: OPN increased significantly in the diabetic group in comparison with control (p<0.001), metformin-treated (p=0.008) and pioglitazone-treated groups (p< 0.001). Furthermore, [alpha]3[beta]1 integrin protein level in diabetic group had a significant difference in comparison with that of the control (p<0.001), metformin-treated (p= 0.026) and pioglitazone-treated groups (p<0.001). Conclusion: OPN and [alpha]3[beta]1 integrin proteins are involved in embryo implantation and their changes in diabetic condition can affect fertility. Treatment with pioglitazone and metformin improved the level of OPN and [alpha]3[beta]1 integrin proteins while pioglitazone was more effective. Keywords: Diabetes mellitus, Endometrium, Osteopontin, [alpha]3[beta]1 integrin. To cite this article: Zarrin Y, Bakhteyari A, Nikpour P, Mostafavi FS, Eskandari N, Matinfar M, et al. A Study on the Presence of Osteopontin and [alpha]3[beta]1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation. J Reprod Infertil. 2020;21(2):87-93.</abstract><pub>Avicenna Research Institute</pub></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Diabetes mellitus Diabetes therapy Embryo Embryonic development Integrins Proteins Type 2 diabetes |
| title | A Study on the Presence of Osteopontin and [alpha]3[beta]1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation |
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