A Study on the Presence of Osteopontin and [alpha]3[beta]1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation

A Study on the Presence of Osteopontin and [alpha]3[beta]1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation

Background: Embryo implantation is a critical and multifactorial phenomenon which can be affected by any alteration in molecular micro construction of endometrium. The aim of the current study was to evaluate the effects of diabetes on osteopontin (OPN) and [alpha]3[beta]1 integrin proteins level at...

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Veröffentlicht in:Faṣlnāmah-i pizishkī-i bārvar va nābārvar 2020-04, Vol.21 (2), p.87
Hauptverfasser: Zarrin, Yasaman, Bakhteyari, Abbas, Nikpour, Parvaneh, Mostafavi, Fatemeh Sadat, Eskandari, Nahid, Matinfar, Mohammad, Aboutorabi, Roshanak
Format: Artikel
Sprache:eng
Schlagworte:
Diabetes mellitus
Diabetes therapy
Embryo
Embryonic development
Integrins
Proteins
Type 2 diabetes
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Zusammenfassung:Background: Embryo implantation is a critical and multifactorial phenomenon which can be affected by any alteration in molecular micro construction of endometrium. The aim of the current study was to evaluate the effects of diabetes on osteopontin (OPN) and [alpha]3[beta]1 integrin proteins level at the time of endometrial receptivity. Methods: Twenty-eight female rats were divided into control, diabetic, pioglitazonetreated and metformin-treated groups. Western blot was performed to determine the OPN and [alpha]3[beta]1 integrin proteins in rats' endometrium at the time of implantation. Data were analyzed by analysis of variance (ANOVA) and p
ISSN:1726-7536