Megaloblastic anaemia in a 9-weeks old infant: A case report

Megaloblastic anaemia due to vitamin B12 and folic acid deficiency is uncommon in infancy and rarely reported in infants below 3 months of age. We hereby report a case of megaloblastic anaemia in a 9-weeks old infant having fever from 7th week of life. Blood picture showed pancytopenia and diagnosis...

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Veröffentlicht in:	Journal of the Pakistan Medical Association 2020-05, Vol.70 (5), p.923
Hauptverfasser:	Afzal, Tehreem, Ashraf, Naveed, Munir, Shahzad, Tabassum, Rabia
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Anemia, Megaloblastic - blood Anemia, Megaloblastic - diagnosis Anemia, Megaloblastic - etiology Anemia, Megaloblastic - therapy Bone Marrow - pathology Breast feeding Care and treatment Case studies Diagnosis Diagnosis, Differential DNA DNA synthesis Early Diagnosis Early Medical Intervention - methods Failure to Thrive - diagnosis Failure to Thrive - etiology Folic acid Folic Acid - administration & dosage Folic Acid - blood Folic acid deficiency Folic Acid Deficiency - complications Folic Acid Deficiency - diagnosis Genetic disorders Humans Infant Infants Male Megaloblastic anemia Pancytopenia - diagnosis Pancytopenia - etiology Pediatric diseases Pediatric research Prenatal Care - standards Treatment Outcome Vitamin B 12 - administration & dosage Vitamin B 12 - blood Vitamin B 12 Deficiency - complications Vitamin B 12 Deficiency - diagnosis Vitamin B12 deficiency Vitamins Vitamins - administration & dosage
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Zusammenfassung:	Megaloblastic anaemia due to vitamin B12 and folic acid deficiency is uncommon in infancy and rarely reported in infants below 3 months of age. We hereby report a case of megaloblastic anaemia in a 9-weeks old infant having fever from 7th week of life. Blood picture showed pancytopenia and diagnosis was confirmed on bone marrow biopsy and serum level of vitamins. Patient positively responded to vitamin B12 and folic acid supplementation. Infants with pancytopenia even younger than 2 months, should also be investigated for vitamin B12 and folate deficiency. Mother of the baby was not antenatally investigated for anaemia. Prompt antenatal diagnosis and treatment of mothers can reduce the incidence in the infants.
ISSN:	0030-9982
DOI:	10.5455/JPMA.23379