Cytokine Profile in Experimental Models of Critical Limb Ischemia in Rats

Cytokine Profile in Experimental Models of Critical Limb Ischemia in Rats

We studied the effect of intramuscular administration of a cellular product (mesenchymal stem cells, conditioned media, and erythropoietin) on cytokine levels in blood serum, conditioned media of bone marrow mononuclears, and calf muscles in Wistar rats with hind limb ischemia. It is shown that the...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2019-11, Vol.168 (1), p.150
Hauptverfasser: Lykov, A.P, Bondarenko, N.A, Poveshchenko, O.V, Kabakov, A.V, Surovtseva, M.A, Kim, I.I, Kazakov, O.V, Poveshchenko, A.F, Yankaite, E.V
Format: Artikel
Sprache:eng
Schlagworte:
Biological products
Cytokines
Erythropoietin
Ischemia
Stem cells
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Zusammenfassung:We studied the effect of intramuscular administration of a cellular product (mesenchymal stem cells, conditioned media, and erythropoietin) on cytokine levels in blood serum, conditioned media of bone marrow mononuclears, and calf muscles in Wistar rats with hind limb ischemia. It is shown that the cellular product reduces the proinflammatory background at the early stages of the experiment and increases the content proangiogenic factors. Key Words: hind limb ischemia; cytokines; cellular product
ISSN:0007-4888
DOI:10.1007/s10517-019-04666-1