Main Aspects of Pharmaceutical Gel Development for Peroral Administration

The main development issues for pharmaceutical gels for peroral administration, a modern dosage form, are reviewed. Patent and literature searches for gel forms for peroral administration were performed. The main development issues for gels for peroral administration are the need for an experimental and science-based approach to correcting the taste, providing the optimal rheological characteristics that determine the stability to aggregation and release of active ingredients from the dosage form, and selecting the packaging and dispensing device for improved therapeutic efficacy. Principles for designing peroral formulations as gels with prolonged release are discussed.