Pharmacogenetic Tests for Antipsychotic-Induced Weight Gain

Pharmacogenetic Tests for Antipsychotic-Induced Weight Gain

Second-generation antipsychotic substances, as compared with first-generation antipsychotics, are more effective in relation to psychotic symptoms and have significantly lower potential for developing extrapyramidal impairments such as parkinsonism and late dyskinesia. However, use of these agents i...

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Veröffentlicht in:Pharmaceutical chemistry journal 2019-10, Vol.53 (7), p.668-671
Hauptverfasser: Zhuravleva, E. O., Vel’ts, N. Yu, Snegireva, I. I., Kutekhova, G. V., Alyautdin, R. N.
Format: Artikel
Sprache:eng
Schlagworte:
Antipsychotic drugs
Complications and side effects
Discussion
Genetic screening
Medicine
Organic Chemistry
Patient compliance
Pharmacogenetics
Pharmacology/Toxicology
Pharmacy
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Zusammenfassung:Second-generation antipsychotic substances, as compared with first-generation antipsychotics, are more effective in relation to psychotic symptoms and have significantly lower potential for developing extrapyramidal impairments such as parkinsonism and late dyskinesia. However, use of these agents is associated with significant weight gain in patients. Advances in the pharmacogenetics of antipsychotic-induced weight gain are analyzed here.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-019-02059-z