Synthesis and Neurotropic Activity of Piperazino-Derivatives of Pyrano[3,4-c]Pyridines

Synthesis and Neurotropic Activity of Piperazino-Derivatives of Pyrano[3,4-c]Pyridines

Methods were developed for synthesizing new substituted piperazine derivatives from chloropyrano- [3,4- c ]pyridines. Pharmacological screening of the synthesized compounds used the well-known corazole antagonism and open field tests. The rotating rod test was used to evaluate the neurotoxicity of t...

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Veröffentlicht in:Pharmaceutical chemistry journal 2019-09, Vol.53 (6), p.495-499
Hauptverfasser: Sirakanyan, S. N., Akopyan, É. K., Paronikyan, R. G., Nazaryan, I. M., Akopyan, A. G., Ovakimyan, A. A.
Format: Artikel
Sprache:eng
Schlagworte:
Antianxiety agents
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Pyridine
Resveratrol
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Zusammenfassung:Methods were developed for synthesizing new substituted piperazine derivatives from chloropyrano- [3,4- c ]pyridines. Pharmacological screening of the synthesized compounds used the well-known corazole antagonism and open field tests. The rotating rod test was used to evaluate the neurotoxicity of the compounds. The tested compounds displayed neurotropic activity. Several compounds of this series exhibited pronounced anticonvulsant and anxiolytic activity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-019-02026-8