Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral [CD8.sup.+] T cells compared with women with BRCA wild-type disease during the early disease course

Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral [CD8.sup.+] T cells compared with women with BRCA wild-type disease during the early disease course

Immunosuppressive myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) are associated with immunologic tolerance and poor prognosis in ovarian cancer (OvCa). We hypothesized that women with germline BRCA1 and BRCA2 mutation-associated (gBRCAm) OvCa would have fewer circulating imm...

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Veröffentlicht in:Oncology letters 2019-10, Vol.18 (4), p.3914
Hauptverfasser: Lee, Jung-Min, Botesteanu, Dana-Adriana, Tomita, Yusuke, Yuno, Akira, Lee, Min-Jung, Kohn, Elise C, Annunziata, Christina M, Matulonis, Ursula, Macdonald, Lauren A, Nair, Jayakumar R, Macneill, Kimberley M, Trepel, Jane B
Format: Artikel
Sprache:eng
Schlagworte:
Bevacizumab
Cell death
Clinical trials
Comparative analysis
Diagnosis
Gene mutation
Immunoglobulins
Lymphocytes
Olaparib
Ovarian cancer
Prognosis
T cells
Women
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Zusammenfassung:Immunosuppressive myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) are associated with immunologic tolerance and poor prognosis in ovarian cancer (OvCa). We hypothesized that women with germline BRCA1 and BRCA2 mutation-associated (gBRCAm) OvCa would have fewer circulating immunosuppressive immune cells compared to those with BRCA wild-type (BRCAwt) disease during their early disease course (5 years post-diagnosis. [CD8.sup.+] T cells among viable [CD45.sup.+] PBMCs and [CTLA-4.sup.+]/[CD8.sup.+] T cells were higher in gBRCAm carriers than patients with BRCAwt, in particular for those
ISSN:1792-1074
DOI:10.3892/ol.2019.10731