Synthesis and Antimicrobial, Antiprotozoal, and Fungistatic Activity of [5-(Amino-, Acylamino-, and 2-Pyridylmethylamino)-1-Alkylbenzimidazol-2-yl]Diphenylmethanols

5-(Amino- and 2-pyridylmethylamino)-1-alkylbenzimidazoles treated sequentially with butyllithium and benzophenone synthesized [5-(amino- and 2-pyridylmethylamino)-1-alkylbenzimidazol-2-yl]diphenylmethanols. (5-Amino-1-methylbenzimidazol-2-yl)diphenylmethanol was converted by acyl chlorides into (5-a...

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Veröffentlicht in:Pharmaceutical chemistry journal 2018-11, Vol.52 (8), p.711-715
Hauptverfasser: Koshchienko, Yu. V., Drobin, Yu. D., Zubenko, A. A., Timoshevskii, D. A., Fetisov, L. N., Bodryakov, A. N.
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Sprache:eng
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Zusammenfassung:5-(Amino- and 2-pyridylmethylamino)-1-alkylbenzimidazoles treated sequentially with butyllithium and benzophenone synthesized [5-(amino- and 2-pyridylmethylamino)-1-alkylbenzimidazol-2-yl]diphenylmethanols. (5-Amino-1-methylbenzimidazol-2-yl)diphenylmethanol was converted by acyl chlorides into (5-acylamino-1-methylbenzimidazol-2-yl)diphenylmethanols. The products were shown to possess bacteriostatic activity against Gram-positive and Gram-negative bacteria ( Staphylococcus aureus , Escherichia coli ), antiprotozoal activity against the ciliate Colpoda steinii , and fungicidal activity against Penicillium italicum .
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-018-1886-2