Synthesis and Antimicrobial, Antiprotozoal, and Fungistatic Activity of [5-(Amino-, Acylamino-, and 2-Pyridylmethylamino)-1-Alkylbenzimidazol-2-yl]Diphenylmethanols
5-(Amino- and 2-pyridylmethylamino)-1-alkylbenzimidazoles treated sequentially with butyllithium and benzophenone synthesized [5-(amino- and 2-pyridylmethylamino)-1-alkylbenzimidazol-2-yl]diphenylmethanols. (5-Amino-1-methylbenzimidazol-2-yl)diphenylmethanol was converted by acyl chlorides into (5-a...
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Veröffentlicht in: | Pharmaceutical chemistry journal 2018-11, Vol.52 (8), p.711-715 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
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Zusammenfassung: | 5-(Amino- and 2-pyridylmethylamino)-1-alkylbenzimidazoles treated sequentially with butyllithium and benzophenone synthesized [5-(amino- and 2-pyridylmethylamino)-1-alkylbenzimidazol-2-yl]diphenylmethanols. (5-Amino-1-methylbenzimidazol-2-yl)diphenylmethanol was converted by acyl chlorides into (5-acylamino-1-methylbenzimidazol-2-yl)diphenylmethanols. The products were shown to possess bacteriostatic activity against Gram-positive and Gram-negative bacteria (
Staphylococcus aureus
,
Escherichia coli
), antiprotozoal activity against the ciliate
Colpoda steinii
, and fungicidal activity against
Penicillium italicum
. |
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ISSN: | 0091-150X 1573-9031 |
DOI: | 10.1007/s11094-018-1886-2 |