Atypical Antipsychotics Induced Metabolic Syndrome/Atipik Antipsikotiklere Bagli Metabolik Sendrom

The use of atypical antipsychotics in patients with schizophrenia is tightly related to the metabolic abnormalities like weight gain, diabetes, dyslipidemia and/or hypertension. Beside of having unique receptor binding features, their heterogeneous receptor binding properties ara also involved in the occurence of the metabolic side effects caused by atypical antipsychotics. It is striking that atypical antipschotics related metabolic side effects have the potential to influence each other in a negative way. Metabolic abnormalities related to atypical antipschotics do not only lead to increase in mortality, but also worsen clinical course and functionality of patients with schizophrenia. Thus, patients treated with atypical antipsychotics should be evaluated routinely with respect to their metabolic states. In this article, metabolic side effects of atypical antipsychotics and their mechanisms were investigated on pharmacological basis. Key words: Schizophrenia, metabolic syndrome, atypical antipsychotics. Sizofreni hastalarinda atipik antipsikotik ilaclarin kullaniminin kilo alimi, diyabet, dislipidemi ve/veya hipertansiyon gibi metabolik anormalliklerle siki sikiya iliskili oldugu bilinmektedir. Metabolik yan etkiler atipik antipsikotiklerin sadece kendilerine has reseptor baglama ozelliklerinin olmasinin disinda bu ilaclarin heterojen reseptor baglama ozellikleriyle de iliskili bulunmustur. Ayrica bu ajanlarla ortaya cikan metabolik yan etkilerin birbirlerini tetikleme potansiyelinin olmasi dikkati cekmektedir. Metabolik bozukluklarla iliskili olarak hastalarda sadece mortalitenin artmadigi, ayni zamanda klinigin kotulestigi ve islevselligin azaldigi da gozlemlenmektedir. Bu nedenlerle atipik antipsikotiklerle tedavi edilen hastalarin rutin olarak metabolik durumunun gozden gecirilmesi gereklidir. Bu derlemede atipik antipsikotiklerin metabolik yan etkileri ve mekanizmalari farmakolojik boyutta incelenmistir. Anahtar sozcukler: Sizofreni, metabolik sendrom, atipik antipsikotikler.