To investigate the relationship between monoamine oxidase A enzyme gene polymorphism and the development of conduct disorder in sexually abused cases/ Cinsel istismar olgularinda monoamin oksidaz A enziminin gen polimorfizmi ve davranim bozuklugu gelismesi ile arasindaki iliskinin incelenmesi

Objective: Our aim in this study is to investigate whether there is a relationship between monoamine oxidase A (MAO-A) gene polymorphisms in sexually abused cases with or without conduct disorder (CD). Methods: Cases were recruited from sexually abused girls (n=52) aged between 13 and 18 who admitted to child psychiatry outpatient clinic. Psychiatric diagnoses were performed by using Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version according to DSM-IV by child psychiatrist. Blood samples were taken from participants and single nucleotide polymorphisms (SNPs) (rs1799835, rs1137070 and rs2072743) were analyzed to detect MAO-A gene polymorphism at Department of Medical Genetics. Results: There was no statistically significant difference between groups with or without CD in terms of rs1799835, rs1137070 and rs2072743 SNPs. Besides, no difference was detected between alleles, genotype frequencies of SNPs and three determined haplotypes in groups with (n=10) or without (n=42) CD in the whole sample. Conclusion: MAO-A gene polymerphism role in the development of CD did not differ between the groups with or without CD in sexually abused cases. It is known that there are a number of factors that play a role of development of CD rather than a diversification of a single gene. Keywords: sexual abuse, conduct disorder, monoamine oxidase, genetic polymorphism Amac: Bu calismanin amaci cinsel istismar magduru olan olgularda davranim bozuklugu (DB) gelistiren ve gelistirmeyen gruplar arasinda monoamin oksidaz A (MAO-A) gen polimorfizmi acisindan iliski olup olmadigini incelemektir. Yontem: Calisma kapsaminda olgu grubu cocuk psikiyatrisi poliklinigine basvuran cinsel istismar magduru 1318 yas araligindaki kiz olgulardan olusturuldu (s=52). Psikiyatrik tanilar DSM-IV tani olcutlerine gore Okul Cagi Cocuklari icin Duygulanim Bozukluklari ve Sizofreni Gorusme Cizelgesi-Simdi ve Yasam Boyu Sekli kullanilarak cocuk psikiyatristi tarafindan yapildi. Katilimcilardan kan ornekleri alinarak MAO-A gen polimorfizminin belirlenmesi amaci ile Tibbi Genetik Anabilim Dalinda tek nukleotid polimorfizmleri (TNP) (rs1799835, rs1137070 ve rs2072743) incelendi. Sonuclar: Katilimcilarin DB gelistiren ve gelistirmeyen gruplarinin rs1137070, rs2072743 ve rs1799835 TNP'leri arasinda istatistiksel olarak anlamli fark saptanmadi. Ayrica tum orneklemde DB olan (s=10) ve olmayan olgularin (s=42) TNP'lerinin allel, genotip frekanslari ve belirle