Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder/Major depresif bozukluk tanili kadin hastalarda yeni bir oksidatif belirtec olarak tiyol/disulfid dengesi

Objective: We aimed to investigate the oxidative stress status in a population of women with untreated major depressive disorder. Methods: Fifty-four female patients with untreated major depressive disorder and 68 female healthy controls were included in the study. A Sociodemographic Form, the Hamilton Anxiety Rating Scale, and the Hamilton Depression Rating Scale (HAM-D) were applied to all the participants. Fasting blood samples were collected from all participants to assess serum thiol/disulphide levels and their pairwise ratios. Results: Native thiol levels were significantly higher and disulphide levels were lower in patients as compared to controls, while total thiol levels were not significantly different between the groups. Disulphide/native thiol and disulphide/total thiol ratios were significantly lower, while the native thiol/total thiol ratio was significantly higher, in the patient group than the control group. There was a negative correlation between HAM-D score and disulphide level, disulphide/native thiol ratio, and disulphide/total ratio, while there was a positive correlation between HAM-D score and native/total thiol ratio, in the patient group. Discussion: This is the first study to investigate dynamic thiol/disulphide homeostasis in women with untreated major depressive disorder. Our results showed dynamic thiol/disulphide homeostasis shifts towards thiol formation which implies an antioxidant reaction in women with untreated major depressive disorder. Keywords: depression, oxidative stress, female, thiol, disulphide Amac: Bu calismada major depresif bozuklugu olan kadin hastalarda oksidatif stres durumunu degerlendirmeyi amacladik. Yontem: Calismaya ilac tedavisi gormeyen major depresif bozuklugu olan 44 kadin hasta ve 68 saglikli kadin alindi. Sosyodemografik Form, Hamilton Anksiyete Derecelendirme Olcegi, Hamilton Depresyon Derecelendirme Olcegi (HAM-D) tum orneklemlere uygulandi. Serum tiyol/disulfid duzeyleri tum katilimcilardan alinmis aclik kan ornekleri degerlendirilerek olculdu. Bulgular: Serum native tiyol duzeyleri hasta grubunda kontrol grubuna gore anlamli duzeyde daha yuksek saptanirken, serum disulfid duzeyleri anlamli duzeyde daha dusuk saptandi. Serum total tiyol duzeyleri acisindan gruplar arasinda anlamli fark yoktu. Hasta grubunda serum disulfid/native tiyol ve serum disulfid/total tiyol oranlari anlamli duzeyde dusuk iken, serum native tiyol/total tiyol orani anlamli duzeyde yuksek saptandi. Hastalarin HAM-D puani