The impact of different 75 g oral glucose tolerance test target ranges within normal limits on neonatal outcomes: A validation study/Normal sinirlardaki farkli 75 gr oral glukoz tolerans test hedef araliklarinin neonatal sonuclar uzerine etkisi: Bir gecerlilik calismasi

Objective: To investigate the impact of different 75 g glucose tolerance test (OGTT) target ranges within normal limits on neonatal outcomes, thus to investigate the validity of 75 g OGTT thresholds. Materials and Methods: The normal 1-hour and 2-hour ranges of 75 g OGTT levels of 110 pregnant women with no gestational diabetes mellitus (GDM) were further divided into three different sub-groups; for the 1 hour as group 1 (140 mg/dL) and for the 2 hour as group 1 (135 mg/dL). Results: For the 1-hour results, there was no statistically significant difference between groups in terms of age, body mass index, multiparity neonatal hypoglycemia, hyperbilirubinemia, neonatal intensive care unit admission, birth weight, and LGT rates; however, the rate of small-for-gestational-age (SGA) infants was significantly higher in group 2 compared with those in group 3. For the 2-hour results, statistically similar results were found between the groups. Conclusion: A 2-hour 75 g OGTT has reliable threshold values for GDM screening. However, because there are still adverse neonatal outcomes in women with OGTT results below the current thresholds and the number of SGA fetuses is higher in the glucose range 120-140 mg/dL of the first hour, the validity of the 75 g OGTT thresholds still needs further investigation. Keywords: Gestational diabetes mellitus, glucose tolerance test, neonatal outcome, screening, pregnancy Amac: Bu calisma normal sinirlardaki farkli 75 gr oral glukoz tolerans test (OGTT) hedef araliklarinin yenidogan sonuclarina etkisini arastirarak 75 gr OGTT esik degerlerinin gecerliligini arastirmak icin yapildi. Gerec ve Yontemler: Gestasyonel diabetes mellitus (GDM) saptanmayan 110 gebe kadininin normal sinirlardaki 1. saat ve 2. saat 75 gr OGTT degerleri 1. saat icin grup 1 (140 mg/dL) olarak ve 2. saat icin grup 1 (135 mg/dL) olarak uc alt gruba ayrildi. Bulgular: Birinci saat sonuclarda yas, vucut kitle indeksi, multiparite, yenidogan hipoglisemi, hiperbilirubinemi, yenidogan yogun bakim unitesi ihtiyaci, dogum agirligi ve LGT oranlari acisindan gruplar arasinda istatistiksel olarak anlamli bir fark yoktu; bununla birlikte, grup 2'deki gebelik yasi icin kucuk (SGA) bebeklerin orani grup 3'e gore istatistiksel olarak anlamli derecede yuksekti. Ikinci saat sonuclar gruplar ar